ARFGEF1 Antibodies

AND ARFGEF1 ELISA kits, ARFGEF1 Proteins

Many biological assays use antibodies to detect ARFGEF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARFGEF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARFGEF1 antibodies...

We validate the specificity of these antibodies to ARFGEF1 by testing them on tissues known to express ARFGEF1 positively and negatively. Browse below to find the ARFGEF1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARFGEF1 Infographic by Boster Bio

All ARFGEF1 Products

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ARFGEF1 Overview

Facts about Brefeldin A-inhibited guanine nucleotide-exchange protein 1.

ARFGEF1 3D structure. Source: alphafold

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1)

Promotes guanine-nucleotide exchange on ARF1 and ARF3.
Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP.

Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the purpose may be independent of its GEF activity.

Gene Information

Human
Gene Name:	ARFGEF1
Uniprot:	Q9Y6D6
Entrez:	10565

Family

Belongs to:

No superfamily

Alternative Names

ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldinA-inhibited); ARFGEP1P200; BIG1p200; Brefeldin A-inhibited GEP 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; D730028O18Rik; DKFZP434L057; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1

Molecular Weight

Mass (kDA):
208.767 kDA

Genomic Context


Human

Location:	8q13.2
Sequence:	8; NC_000008.11 (67174298..67343824, complement)

Tissue Specificity

Expressed in placenta, lung, heart, brain, kidney and pancreas.

Subcellular Localizations

Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Nucleus. Nucleus, nucleolus. Nucleus matrix. Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.

Diseases

Tissue Adhesions
Microcephaly
Liver Carcinoma
Malignant Neoplasm Of Breast
Glioma
Protrusion
Congenital Disorders Of Glycosylation
Congenital Disorders
Patient Dependence On
Malignant Neoplasms

Hemolytic-uremic Syndrome
Mammary Neoplasms
Liver Neoplasms
Ectopic Tissue

Interacting Proteins

ARFGEF2
KANK1
KIF21A
MYCBP
NCL

PDE3A

Pathways

Transport
Localization
Secretory Pathway
Cell Migration
Glycosylation
Protein Transport
Rna Interference
Cell Adhesion
Proteolysis
Protein Secretion
Demethylation
Methylation
Protein Glycosylation

Cell Death
Cell Growth
Golgi Organization
Wound Healing
Regulation Of Protein Transport
Nucleocytoplasmic Transport
Lipid Transport

PTMs

Ribosylation
Phosphorylation
Demethylation

Cleavage
Glycosylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARFGEF1

References

PMID: 10212200 by Togawa A., et al. Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

PMID: 10393931 by Mansour S.J., et al. p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A.