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- Table of Contents
Facts about Methylthioribulose-1-phosphate dehydratase.
May inhibit the CASP1-related inflammatory reaction (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. .
Human | |
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Gene Name: | APIP |
Uniprot: | Q96GX9 |
Entrez: | 51074 |
Belongs to: |
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aldolase class II family |
APAF1 interacting protein; APAF1-interacting protein; APIP2; CGI29; CGI-29; dJ179L10.2; EC 4.2.1.109; Mmrp19; MTRu-1-P dehydratase; probable methylthioribulose-1-phosphate dehydratase
Mass (kDA):
27.125 kDA
Human | |
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Location: | 11p13 |
Sequence: | 11; NC_000011.10 (34882295..34916411, complement) |
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
Cytoplasm.
PMID: 15262985 by Cho D.-H., et al. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf- 1-interacting protein.
PMID: 23285211 by Mary C., et al. Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway.