APH1A Antibodies

AND APH1A ELISA kits, APH1A Proteins

Many biological assays use antibodies to detect APH1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APH1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APH1A antibodies...

We validate the specificity of these antibodies to APH1A by testing them on tissues known to express APH1A positively and negatively. Browse below to find the APH1A antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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APH1A Infographic by Boster Bio

All APH1A Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-APH1a Antibody Picoband®

3 Q&As

Human, Mouse, Rat

$370
Cat # PB9421
100 μg/vial

Anti-APH1 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$449
Cat # A04859
0.1 mg

APH1A (NM_001077628) Human Over-expression Lysate

Human

$628
Cat # LS051107
100 µg

Anti-APH1A Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # A04859-1
100 μg/vial

APH1A Overview

Facts about Gamma-secretase subunit APH-1A.

APH1A 3D structure. Source: alphafold

Gamma-secretase subunit APH-1A (APH1A)

Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335). Required for normal gamma- secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254).

The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). .

Gene Information

Human
Gene Name:	APH1A
Uniprot:	Q96BI3
Entrez:	51107

Family

Belongs to:

APH-1 family

Alternative Names

6530402N02Rik; anterior pharynx defective 1 homolog A (C. elegans); APH-1; APH1A; APH-1A; aph-1alpha; CGI-78; gamma-secretase subunit APH-1A; Presenilin-stabilization factor; PSF

Molecular Weight

Mass (kDA):
28.996 kDA

Genomic Context


Human

Location:	1q21.2
Sequence:	1; NC_000001.11 (150265399..150282179, complement)

Tissue Specificity

Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.

Diseases

Alzheimer's Disease
Plaque, Amyloid
Alzheimer Disease, Familial
Neurodegenerative Disorders
Hypoxia
Tumor Angiogenesis
Tissue Adhesions
Shwachman Syndrome
Senile Plaques
Sclerosis
Primary Lateral Sclerosis
Dementia
Amyotrophic Lateral Sclerosis

Coronary Artery Disease
Brain Hypoxia
Coinfection
Cerebrovascular Accident
Dental Plaque
Chimera Disorder
Senile Cerebral Amyloid Angiopathy

Interacting Proteins

NCSTN

Pathways

Proteolysis
Pathogenesis
Localization
Secretory Pathway
Glycosylation
Rna Interference
Secretion
Cell Death
Angiogenesis
Cell Adhesion
Transport
Aging
Tissue Development

Chemotaxis
Macroautophagy
Mrna Transcription
Translation
Receptor-mediated Endocytosis
Regulation Of Cell Death
Chemokinesis

PTMs

Cleavage
Glycosylation
Gamma-cleavage
Palmitoylation

Phosphorylation
Biotinylation
Reduction
Ubiquitination

Research Areas

GPCR
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APH1A

References

PMID: 12297508 by Lee S.-F., et al. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.

PMID: 12110170 by Francis R., et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma- secretase cleavage of betaAPP, and presenilin protein accumulation.