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- Table of Contents
Facts about AP-3 complex subunit mu-1.
It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Human | |
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Gene Name: | AP3M1 |
Uniprot: | Q9Y2T2 |
Entrez: | 26985 |
Belongs to: |
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adaptor complexes medium subunit family |
adaptor-related protein complex 3, mu 1 subunit; AP-3 adapter complex mu3A subunit; MGC22164; mu-3A subunit; mu3A-adaptin
Mass (kDA):
46.939 kDA
Human | |
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Location: | 10q22.2 |
Sequence: | 10; NC_000010.11 (74120012..74151067, complement) |
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
PMID: 10024875 by Dell'Angelica E.C., et al. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor.
PMID: 29028839 by Ward C., et al. Interaction of the Human Respiratory Syncytial Virus matrix protein with cellular adaptor protein complex 3 plays a critical role in trafficking.