AP2S1 Antibodies

AND AP2S1 ELISA kits, AP2S1 Proteins

Many biological assays use antibodies to detect AP2S1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AP2S1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AP2S1 antibodies...

We validate the specificity of these antibodies to AP2S1 by testing them on tissues known to express AP2S1 positively and negatively. Browse below to find the AP2S1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AP2S1 Infographic by Boster Bio

All AP2S1 Products

Product

Figures

Specificity

Applications

Price

Anti-AP-2 complex subunit sigma AP2S1 Antibody

Human, Mouse, Rat

$405
Cat # A07176
100ul

AP2S1 (NM_004069) Human Recombinant Protein

$1249
Cat # PROTP53680
20 µg

Anti-AP2S1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IP, WB

$370
Cat # M07176
100 μl/vial

Anti-AP2S1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M07176-1
100 μl/vial

AP2S1 (NM_004069) Human Over-expression Lysate

Human

$628
Cat # LS001175
100 µg

AP2S1 Overview

Facts about AP-2 complex subunit sigma.

AP2S1 3D structure. Source: alphafold

AP-2 complex subunit sigma (AP2S1)

Part of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways.

Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for combination with the early endosome.

Gene Information

Human
Gene Name:	AP2S1
Uniprot:	P53680
Entrez:	1175

Family

Belongs to:

adaptor complexes small subunit family

Alternative Names

Adapter-related protein complex 2 sigma subunit; Adaptor protein complex AP-2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; AP17HA2 17 kDa subunit; AP-2 complex subunit sigma; CLAPS2AP17-DELTA; Clathrin assembly protein 2 small chain; Clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; clathrin-associated/assembly/adaptor protein, small 2 (17kD); Plasma membrane adaptor AP-2 17 kDa protein; sigma2-adaptin

Molecular Weight

Mass (kDA):
17.018 kDA

Genomic Context


Human

Location:	19q13.32
Sequence:	19; NC_000019.10 (46838136..46850846, complement)

Subcellular Localizations

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.

Diseases

Familial Hypocalciuric Hypercalcaemia
Leukemia
Hypercalcemia

Interacting Proteins

AAGAB

Pathways

Transport
Clathrin-mediated Endocytosis
Proteolysis
Endocytosis

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AP2S1

References

PMID: 9040778 by Winterpacht A., et al. Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3.

PMID: 9767099 by Holzmann K., et al. A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17.