ALX homeobox protein 1 Antibodies

AND ALX1 ELISA kits, ALX homeobox protein 1 Proteins

Many biological assays use antibodies to detect ALX homeobox protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ALX homeobox protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ALX homeobox protein 1 antibodies...

We validate the specificity of these antibodies to ALX homeobox protein 1 by testing them on tissues known to express ALX1 positively and negatively. Browse below to find the ALX1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ALX1 Infographic by Boster Bio

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ALX1 (NM_006982) Human Over-expression Lysate

Human

$628
Cat # LS008092
100 µg

ALX1 Overview

Facts about ALX homeobox protein 1.

ALX1 3D structure. Source: alphafold

ALX homeobox protein 1 (ALX1)

Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most likely modulates the expression of genes involved in the growth of mesenchyme-derived craniofacial structures.

Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).

Gene Information

Human
Gene Name:	ALX1
Uniprot:	Q15699
Entrez:	8092

Family

Belongs to:

paired homeobox family

Alternative Names

ALX homeobox 1; CART-1; CART1ALX homeobox protein 1; Cartilage homeoprotein 1; cartilage paired-class homeoprotein 1; FND3

Molecular Weight

Mass (kDA):
36.961 kDA

Genomic Context


Human

Location:	12q21.31
Sequence:	12; NC_000012.12 (85280220..85301784)

Tissue Specificity

Cartilage and cervix tissue.

Subcellular Localizations

Nucleus.

Diseases

Chondrosarcoma
Neoplasms
Microphthalmos
Craniofacial Abnormalities
Orbital Separation Excessive
Carcinoma
Dysplasia
Anencephaly
Malignant Paraganglionic Neoplasm
Crest Syndrome
Frontonasal Dysplasia
Holt-oram Syndrome

Uterine Cervical Neoplasm
Congenital Musculoskeletal Anomalies
Bone Neoplasms
Teratogenic Effect
Malignant Tumor Of Cervix
Congenital Cerebral Hernia

Interacting Proteins

IPO13

Pathways

Localization
Chondrocyte Differentiation
Neural Tube Closure
Limb Development
Tube Development
Tube Closure
Neural Tube Development
Endochondral Ossification
Tube Fusion
Endocytosis
Tube Morphogenesis
Ossification
Cartilage Development

Cervix Development
Translation
Limb Morphogenesis
Dedifferentiation
Cell Growth
Interphase
Chromatin Remodeling

PTMs

Phosphorylation
Cleavage

Acetylation
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALX1

References

PMID: 8756334 by Gordon D.F., et al. Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA.

PMID: 9753625 by Cai R.L.; Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites.