AKR1D1 Antibodies

AND AKR1D1 ELISA kits, AKR1D1 Proteins

Many biological assays use antibodies to detect AKR1D1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKR1D1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKR1D1 antibodies...

We validate the specificity of these antibodies to AKR1D1 by testing them on tissues known to express AKR1D1 positively and negatively. Browse below to find the AKR1D1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AKR1D1 Infographic by Boster Bio

All AKR1D1 Products

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Product

Figures

Specificity

Applications

Price

Anti-AKR1D1 Antibody Picoband®

6 Q&As

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # A05278-1
100 μg/vial

Anti-AKR1D1 Antibody Picoband® (monoclonal, 6I4)

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # M05278
100 μg/vial

Anti-AKR1D1 Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A05278-2
100 μg/vial

AKR1D1 (NM_005989) Human Recombinant Protein

$813
Cat # PROTP51857
20 µg

AKR1D1 Overview

Facts about Aldo-keto reductase family 1 member D1.

AKR1D1 3D structure. Source: alphafold

Aldo-keto reductase family 1 member D1 (AKR1D1)

Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.

Gene Information

Human
Gene Name:	AKR1D1
Uniprot:	P51857
Entrez:	6718

Family

Belongs to:

aldo/keto reductase family

Alternative Names

3o5bred; Aldo-keto reductase family 1 member D1,3-oxo-5-beta-steroid 4-dehydrogenase; aldo-keto reductase family 1, member D1 (delta4-3-ketosteroid-5-beta-reductase); CBAS2; Delta(4)-3-oxosteroid 5-beta-reductase; EC 1.3.1.3; SRD5B1beta polypeptide 1 (3-oxo-5 beta-steroid delta4-dehydrogenase beta 1)

Molecular Weight

Mass (kDA):
37.377 kDA

Genomic Context


Human

Location:	7q33
Sequence:	7; NC_000007.14 (138076459..138118305)

Tissue Specificity

Highly expressed in liver. Expressed in testis and weakly in colon.

Subcellular Localizations

Cytoplasm.

Diseases

Liver Failure
Endometriosis, Site Unspecified
Malignant Neoplasms
Malignant Neoplasm Of Prostate
Cholestasis
Cholangiocarcinoma
Premature Obstetric Labor
Liver Diseases
Neonatal Hepatitis
Inborn Errors Of Metabolism
Malignant Neoplasm Of Breast
Endometrial Polyp

Liver Damage
Benign Prostatic Hypertrophy
Carcinoma
Diseases In Twins
Asthma
Bipolar Disorder
Influenza

Pathways

Parturition
Protein Folding
Pathogenesis
Excretion

PTMs

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKR1D1

References

PMID: 7508385 by Kondo K.-H., et al. Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta- reductase and substrate specificity of the expressed enzyme.

PMID: 11342103 by Charbonneau A., et al. Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme.