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AHCYL1 Antibodies
AND AHCYL1 ELISA kits, AHCYL1 Proteins
Many biological assays use antibodies to detect AHCYL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AHCYL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AHCYL1 antibodies...
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AHCYL1 Infographic by Boster Bio
All AHCYL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08908-2
100 μg/vial
Cat # A08908-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M08908
100 μg/vial
Cat # M08908
100 μg/vial
AHCYL1 Overview
Facts about S-adenosylhomocysteine hydrolase-like protein 1.
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)
Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5- trisphosphate competing for the frequent binding site and acting as endogenous'pseudoligand' whose inhibitory activity could be modulated by its phosphorylation status.
From the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5- trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | AHCYL1 |
| Uniprot: | O43865 |
| Entrez: | 10768 |
Family
| Belongs to: |
|---|
| adenosylhomocysteinase family |
Alternative Names
adenosylhomocysteinase-like 1; AdoHcyase 2; DCAL; DC-expressed AHCY-like molecule; dendritic cell expressed AHCY-like protein; inositol 14,5-trisphosphate receptor-binding protein; IRBIT; PRO0233; putative adenosylhomocysteinase 2; S-adenosyl homocysteine hydrolase homolog; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein 1; S-adenosyl-L-homocysteine hydrolase 2; XPVKONAEC 3.3.1.1
Molecular Weight
Mass (kDA):
58.951 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.3 |
| Sequence: | 1; NC_000001.11 (109984765..110023742) |
Tissue Specificity
Expressed in dendritic cells.
Subcellular Localizations
Endoplasmic reticulum. Cytoplasm, cytosol. Microsome. Apical cell membrane. Associates with membranes when phosphorylated, probably through interaction with ITPR1.
Diseases
- Malignant Neoplasms
- Neoplasms
- Adenocarcinoma
- Influenza
- Cell Transformation, Neoplastic
- Melanoma
- Malignant Paraganglionic Neoplasm
- Carcinogenesis
- Virus Diseases
Interacting Proteins
- BID
- CDKN2C
- GEM
- HEXIM2
- JOSD2
- LRRK2
- MEOX2
- PPL
- PRDM6
- PSMD9
Pathways
- Methylation
- Drug Resistance
- Translation
- Oviduct Development
- Innate Immune Response
- Dna Methylation
- Immune Response
- Chromosome Condensation
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AHCYL1
bosterbio.com/bosterbio-gene-info-cards/AHCYL1
References
PMID: 11904675 by Dekker J.W., et al. Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation.
PMID: 12878157 by Imabayashi H., et al. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.