AF4/FMR2 family member 1 Antibodies

AND AFF1 ELISA kits, AF4/FMR2 family member 1 Proteins

Many biological assays use antibodies to detect AF4/FMR2 family member 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AF4/FMR2 family member 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AF4/FMR2 family member 1 antibodies...

We validate the specificity of these antibodies to AF4/FMR2 family member 1 by testing them on tissues known to express AFF1 positively and negatively. Browse below to find the AFF1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AFF1 Infographic by Boster Bio

All AFF1 Products

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Product

Figures

Specificity

Applications

Price

Anti-AF4 AFF1 Antibody

7 Q&As

Human, Mouse

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A02590-1
100ul

Anti-AF4/FMR2 family member 1 AFF1 Antibody

Human, Rat

IF, IHC, ICC, WB

$405
Cat # A02590
100ul

AF4 (AFF1) (NM_005935) Human Over-expression Lysate

Human

$960
Cat # LS004299
100 µg

AFF1 Overview

Facts about AF4/FMR2 family member 1.

AFF1 3D structure. Source: alphafold

AF4/FMR2 family member 1 (AFF1)

Gene Information

Human
Gene Name:	AFF1
Uniprot:	P51825
Entrez:	4299

Family

Belongs to:

AF4 family

Alternative Names

AF-4; AF4/FMR2 family member 1; AF4/FMR2 family, member 1; AF4myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);translocated to, 2; ALL1-fused gene from chromosome 4 protein; FEL; MLLT2MGC134969; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 2; PBM1; pre-B-cell monocytic leukemia partner 1; Protein AF-4; Protein FEL; Proto-oncogene AF4

Molecular Weight

Mass (kDA):
131.422 kDA

Genomic Context


Human

Location:	4q21.3-q22.1
Sequence:	4; NC_000004.12 (86934606..87141054)

Subcellular Localizations

Nucleus.

Diseases

Leukemia
Acute Lymphocytic Leukemia
Chromosomal Translocation
Acute Leukemia
Precursor B-cell Lymphoblastic Leukemia-lymphoma
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Leukemogenesis
Neoplasm, Residual
Burkitt Lymphoma
Malignant Neoplasms
Cytogenetic Abnormality

Cell Transformation, Neoplastic
Ataxia
Fraxe Syndrome
Lymphoma
Lupus Erythematosus, Systemic
Chromosome Breakage

Interacting Proteins

MLLT3

Pathways

Localization
Oncogenesis
Methylation
Cell Death
Cell Cycle
Pathogenesis
Rna Interference
Cell Proliferation
Cellular Homeostasis
Dna Repair
Cell Cycle Arrest
Translation

Cellular Localization
Necrotic Cell Death
Dna Modification
Interphase
Mating
Histone Methylation
Meiosis

PTMs

Cleavage
Methylation

Phosphorylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AFF1

References

PMID: 8506309 by Nakamura T., et al. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

PMID: 8443374 by Morrissey J., et al. A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.