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3 Citations 9 Q&As
1 Citations 7 Q&As
Facts about A disintegrin and metalloproteinase with thrombospondin motifs 4.
Could also be a critical element in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan in the'392-Glu-.
Human | |
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Gene Name: | ADAMTS4 |
Uniprot: | O75173 |
Entrez: | 9507 |
Belongs to: |
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No superfamily |
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADAMTS2; ADAMTS-2; ADAMTS4; ADAM-TS4; ADAMTS-4; ADMP-1; ADMP-1EC 3.4.24.82; Aggrecanase 1; aggrecanase-1; EC 3.4.24; KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4
Mass (kDA):
90.197 kDA
Human | |
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Location: | 1q23.3 |
Sequence: | 1; NC_000001.11 (161184302..161202339, complement) |
Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278).
Secreted, extracellular space, extracellular matrix.
If you are an expert in science and are looking for a marker that uses ADAMTS4, you may want to consider a product called Boster Bio. The product allows scientists to submit their results for species, applications, as well as special samples. In return, you will be awarded product credits for your work. This product is accessible to scientists across the world. Continue reading to find out more.
Boster Bio's antiBax monoclonal antibodies are a powerful tool for detecting Bax, an Apoptosis marker. This antibody was developed for use in cell cultures. It was derived from a rabbit polyclonal antifGF2, anti-C1QBP Anti-VDAC, anti-b-actin, and anti VDAC antibody. The primary and second antibodies were employed in the following tests: 1% skim and TBST.
Boster Bio Anti-Bax antibody (Apoptoses marker) has multiple antigen-specificities. It is tested for compatibility with different species. It has been proven that it can bind to Rat, Mouse, Rat and Human cells. It has been validated for multiple assays including IHC, WB, and WFA.
BAX is one of the Bcl-2 group that includes proteins that regulate apoptosis. While widely recognized as an anti-apoptotic protein scientists believe BAX is a pro-apoptotic protein. Different isoforms of BAX regulate the process of Apoptosis. BAX beta is a beta carboxyl terminus and Bcl-2 alpha an hydrophobic transmembrane. It also forms homodimers and heterodimers along with other proteins belonging to the BCL-2 family.
Boster Bio produced the anti-Bax monoclonal antibody after immunizing BALB/c mice with the BHRF1. After the antibody was generated by hybridoma cellsas described by Tsai and al. the mice were killed. (58). Immunostaining the BHRF1 monoclonal antibody in rabbit antiserum helped us select the anti-Bax clone having the highest Reactivity.
Therapeutic monoclonal antibody is a well-established anti-cancer drug. Monoclonal antibodies target tumor antigens and immune checkpoints. These are associated with a variety of malignancies. They are expensive and can cause adverse reactions. Some patients might be resistant to monoclonal antibodies. In such instances, patients may need to undergo an active immunization tumor-specific antigens.
Tests on mice's DNA have demonstrated that active immunization with this antibody increased the tumor-specific levelecto umi3and cKi67compatrd to upssove immunization with tmPD1-erived fmimotped Aftive immunization wstimlate s FAS ignnd cxperssibon The pmi3arotein ss a wellsapoptotic parker. TBoh a ti-Bax monoclonal antibodyes arn the tonoclonal antibody imPD1are exfertive im provmotng the hdeah a tdhdeah ao uells.
PMID: 10356395 by Tortorella M.D., et al. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
PMID: 16723216 by Wainwright S.D., et al. An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients.
*More publications can be found for each product on its corresponding product page