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ADAMTS13 Antibodies
AND ADAMTS13 ELISA kits, ADAMTS13 Proteins
Many biological assays use antibodies to detect ADAMTS13, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAMTS13 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAMTS13 antibodies...
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ADAMTS13 Infographic by Boster Bio
All ADAMTS13 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0927
96 wells/kit, with removable strips.
Cat # EK0927
96 wells/kit, with removable strips.
Human
ELISA
$500
Cat # EZ0927
For 5 plates, 96 wells each
Cat # EZ0927
For 5 plates, 96 wells each
ADAMTS13 Overview
Facts about A disintegrin and metalloproteinase with thrombospondin motifs 13.
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13)
Cleaves the vWF multimers in plasma into smaller kinds thereby controlling vWF-mediated platelet thrombus formation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ADAMTS13 |
| Uniprot: | Q76LX8 |
| Entrez: | 11093 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; ADAMTS13; ADAM-TS13; ADAMTS-13; DKFZp434C2322; EC 3.4.24.14; EC 3.4.24.82; EC 3.4.24.87; FLJ42993; MGC118899; MGC118900; TTP; TTPADAM-TS 13; vWF-cleaving protease; vWF-CP; vWF-CPC9orf8; VWFCPvon Willebrand factor-cleaving protease
Molecular Weight
Mass (kDA):
153.604 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.2 |
| Sequence: | 9; NC_000009.12 (133414339..133459403) |
Tissue Specificity
Plasma. Expressed primarily in liver.
Subcellular Localizations
Secreted. Secretion enhanced by O-fucosylation of TSP type-1 repeats.
Diseases
- Purpura, Thrombotic Thrombocytopenic
- Purpura
- Thrombocytopenic Purpura
- Von Willebrand Disease
- Thrombotic Microangiopathies
- Thrombosis
- Hemolytic-uremic Syndrome
- Anemia
- Anemia, Hemolytic
- Disease Of Capillaries
- Uremia Syndrome
- Microangiopathic Hemolytic Anemia
- Acquired Thrombotic Thrombocytopenic Purpura
Interacting Proteins
- VWF
Pathways
- Pathogenesis
- Proteolysis
- Platelet Aggregation
- Coagulation
- Secretion
- Hemostasis
- Platelet Activation
- Complement Activation
- Inflammatory Response
- Fibrinolysis
- Localization
- Cell Activation
- Endothelial Cell Activation
PTMs
- Cleavage
- Oxidation
- Reduction
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAMTS13
bosterbio.com/bosterbio-gene-info-cards/ADAMTS13
References
PMID: 11574066 by Soejima K., et al. A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease?
PMID: 11557746 by Zheng X., et al. Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura.