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Acot1 Antibodies
AND Acot1 ELISA kits, Acot1 Proteins
Many biological assays use antibodies to detect Acot1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acot1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acot1 antibodies...
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Acot1 Overview
Facts about Acyl-coenzyme A thioesterase 1.
Acyl-coenzyme A thioesterase 1 (Acot1)
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. True acyl-CoA thioesterase being highly specific for saturated C12-C20 acyl-CoAs, with only a very low action with decanoyl-CoA as substrate.
Most active on myristoyl- and - palmitoyl-CoA. Introduction of a single or two double bonds decreases the activity to approximately half.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Acot1 |
| Uniprot: | O55137 |
| Entrez: | 26897 |
Family
| Belongs to: |
|---|
| C/M/P thioester hydrolase family |
Alternative Names
ACH2; acyl-CoA thioesterase 1Long chain acyl-CoA thioester hydrolase; acyl-coenzyme A thioesterase 1; CTE1; CTE-1; CTE-I; CTE-Ib; EC 3.1.2.2; Inducible cytosolic acyl-coenzyme A thioester hydrolase; LACH2; Long chain acyl-CoA hydrolase
Molecular Weight
Mass (kDA):
46.136 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 12 D1|12 39.0 cM |
| Sequence: | 12; |
Tissue Specificity
Expressed in heart, kidney, brown adipose tissue, white adipose tissue, adrenal gland and muscle.
Diseases
- Cell Transformation, Neoplastic
- Cardiomyopathies
- Maternal Exposure
- Obesity
- Malignant Paraganglionic Neoplasm
- Diabetes Mellitus
- Hypoglycemia
Pathways
- Fatty Acid Oxidation
- Lactation
- Insulin Secretion
- Cell Differentiation
- Fatty Acid Beta-oxidation
- Autophagy
PTMs
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Acot1
bosterbio.com/bosterbio-gene-info-cards/Acot1
References
PMID: 10567408 by Hunt M.C., et al. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism.
PMID: 11330065 by Hunt M.C., et al. Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism.