ABRAXAS2 Antibodies

AND ABRAXAS2 ELISA kits, ABRAXAS2 Proteins

Many biological assays use antibodies to detect ABRAXAS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABRAXAS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABRAXAS2 antibodies...

We validate the specificity of these antibodies to ABRAXAS2 by testing them on tissues known to express ABRAXAS2 positively and negatively. Browse below to find the ABRAXAS2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABRAXAS2 Infographic by Boster Bio

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ABRAXAS2 (NM_032182) Human Over-expression Lysate

Human

$628
Cat # LS023172
100 µg

ABRAXAS2 Overview

Facts about BRISC complex subunit Abraxas 2.

ABRAXAS2 3D structure. Source: alphafold

BRISC complex subunit Abraxas 2 (ABRAXAS2)

Component of the BRISC complicated, a multiprotein complex that specifically cleaves'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein which assembles the various components of the BRISC complicated and keeps them in the cytoplasm (PubMed:20656690).

Plays a role in regulating the onset of apoptosis via its role in regulating'Lys- 63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665).

Gene Information

Human
Gene Name:	ABRAXAS2
Uniprot:	Q15018
Entrez:	23172

Family

Belongs to:

FAM175 family

Alternative Names

BRISC complex subunit Abraxas 2

Molecular Weight

Mass (kDA):
46.901 kDA

Genomic Context


Human

Location:	10q26.13
Sequence:	10; NC_000010.11 (124801803..124836670)

Tissue Specificity

Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain (PubMed:21195082).

Subcellular Localizations

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. A minor proportion is detected in the nucleus (PubMed:21282113, PubMed:22974638). Translocates into the nucleus in response to DNA damage (PubMed:25283148). Directly binds to microtubules and is detected at the minus end of K-fibers (PubMed:26195665). Co-localizes with NUMA1 at mitotic spindle poles (PubMed:26195665).

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABRAXAS2

References

PMID: 17525340 by Wang B., et al. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

PMID: 19214193 by Cooper E.M., et al. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1.