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- Table of Contents
Facts about ATP-binding cassette sub-family E member 1.
Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Human | |
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Gene Name: | ABCE1 |
Uniprot: | P61221 |
Entrez: | 6059 |
Belongs to: |
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ABC transporter superfamily |
2'-5'-oligoadenylate-binding protein; ATP-binding cassette, sub-family E (OABP), member 1; huHP68; OABP; Ribonuclease 4 inhibitor; ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent) inhibitor; RLIABC38; RNase L inhibitor; RNASEL1; RNASELIRNS4IATP-binding cassette sub-family E member 1
Mass (kDA):
67.314 kDA
Human | |
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Location: | 4q31.21 |
Sequence: | 4; NC_000004.12 (145098311..145129524) |
Cytoplasm. Mitochondrion. Localized to clusters of virus formation at the plasma membrane.
PMID: 7539425 by Bisbal C., et al. Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway.
PMID: 8641422 by Aubry F., et al. Chromosomal localization and expression pattern of the RNase L inhibitor gene.