ABCC2 Antibodies

AND ABCC2 ELISA kits, ABCC2 Proteins

Many biological assays use antibodies to detect ABCC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCC2 antibodies...

We validate the specificity of these antibodies to ABCC2 by testing them on tissues known to express ABCC2 positively and negatively. Browse below to find the ABCC2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABCC2 Infographic by Boster Bio

All ABCC2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MRP2 ABCC2 Rabbit Monoclonal Antibody

1 Citations 5 Q&As

Human

Flow Cytometry, IF, ICC, WB

$370
Cat # M00974
100 μl

Anti-MRP2/ABCC2 Antibody Picoband®

7 Citations 1 Q&As

Human

IHC, WB

$370
Cat # A00974-1
100 μg/vial

Anti-MRP2 ABCC2 Antibody

Human

Flow Cytometry, IHC, ICC, WB

$405
Cat # A00974
100ul

Anti-MRP2 (ABCC2) Mouse Monoclonal Antibody [Clone ID: OTI5C3]

Human, Rat

IHC, WB

$523
Cat # M00974-1
100 µl

ABCC2 Overview

Facts about Canalicular multispecific organic anion transporter 1.

ABCC2 3D structure. Source: alphafold

Canalicular multispecific organic anion transporter 1 (ABCC2)

Mediates hepatobiliary excretion of numerous organic anions. May be the cellular cisplatin transporter.

Gene Information

Human
Gene Name:	ABCC2
Uniprot:	Q92887
Entrez:	1244

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; CMOAT1; CMOATABC30; cMRP; DJS; KIAA1010; MRP2ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2

Molecular Weight

Mass (kDA):
174.207 kDA

Genomic Context


Human

Location:	10q24.2
Sequence:	10; NC_000010.11 (99782602..99853741)

Tissue Specificity

Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Neoplasms
Hyperbilirubinemia
Cholestasis
Carcinoma
Jaundice, Chronic Idiopathic
Liver Carcinoma
Liver Diseases
Epilepsy
Hepatotoxicity
Mammary Neoplasms
Hiv Infections

Liver Neoplasms
Cholangiocarcinoma
Conjugated Hyperbilirubinemia
Ovarian Neoplasm
Malignant Neoplasm Of Lung
Icterus
Injury To Liver

Interacting Proteins

NFKB1

Pathways

Transport
Excretion
Localization
Secretion
Drug Resistance
Drug Transport
Conjugation
Intestinal Absorption
Organic Anion Transport
Anion Transport
Pathogenesis
Dna Repair
Transepithelial Transport

Gene Silencing
Cell Proliferation
Regeneration
Cellular Localization
Reverse Transcription
Glomerular Filtration
Methotrexate Transport

PTMs

Phosphorylation
Hydroxylation
Glycosylation
Carboxylation
Biotinylation
Reduction
Methylation

Sumoylation
Nitrosylation
Amidation
Ubiquitination
Nitration
Cleavage
Oxidation

Deglycosylation

Research Areas

ABC Transporters
Amino Acids, Drugs and other small molecules
Cancer
Diabetes Research
Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCC2

References

PMID: 8797578 by Taniguchi K., et al. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

PMID: 8662992 by Buechler M., et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.

7 Publications of Boster ABCC2 Antibodies & ELISA Kits

PubMed ID: 10.3892/ijo.2016.3442, Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovar...
PubMed ID: 10.1186/1479-5876-6-55, Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of...
PubMed ID: 10.1155/2021/5566078, The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar...
PubMed ID: 10.1155/2010/915046, Association of ABCC2 and CDDP-Resistance in Two Sublines Resistant to CDDP Deriv...
PubMed ID: -, Songsong Wang,Xiao Xiao,Ao Li,Peng Li,"The Herbal Constituents in An-Gong-Niu-Hu...
PubMed ID: 33317360, Huang J,Wang Q,Chen M,Bi Y,Shi H,Zhou K. Effects of psoralen on hepatic bile aci...
PubMed ID: 20628484, Association of ABCC2 and CDDP-resistance in two sublines resistant to CDDP deriv...

*More publications can be found for each product on its corresponding product page