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ABCA7 Antibodies
AND ABCA7 ELISA kits, ABCA7 Proteins
Many biological assays use antibodies to detect ABCA7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCA7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCA7 antibodies...
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ABCA7 Overview
Facts about Phospholipid-transporting ATPase ABCA7.
Phospholipid-transporting ATPase ABCA7 (ABCA7)
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and might function in apolipoprotein-mediated phospholipid efflux from cells.
May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCA7 |
| Uniprot: | Q8IZY2 |
| Entrez: | 10347 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABCA-SSN; ABCXATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7; Autoantigen SS-N; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025; Macrophage ABC transporter
Molecular Weight
Mass (kDA):
234.35 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (1040107..1065572) |
Tissue Specificity
Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney (By similarity).; [Isoform 2]: Cytoplasm. Endoplasmic reticulum. May localize to the endoplasmi
Diseases
- Alzheimer's Disease
- Malignant Neoplasms
- Tangier Disease
- Carcinoma
- Neoplasms
- Sjogren's Syndrome
- Epithelial Ovarian Cancer
- Nervousness
- Atherosclerosis
- Neoplasm Metastasis
- Hereditary Diseases
- Inflammation
Pathways
- Transport
- Cholesterol Efflux
- Lipid Homeostasis
- Lipid Transport
- Localization
- Phagocytosis
- Pathogenesis
- Phospholipid Efflux
- Secretion
- Cholesterol Transport
- Lactation
- Cholesterol Homeostasis
- Aging
PTMs
- Phosphorylation
- Biotinylation
Research Areas
- ABC Transporters
- Cellular Markers
- Cholesterol Metabolism
- Glia Markers
- Golgi Apparatus Markers
- Lipid and Metabolism
- Neuroscience
- Plasma Membrane Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCA7
bosterbio.com/bosterbio-gene-info-cards/ABCA7
References
PMID: 10873640 by Kaminski W.E., et al. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7).
PMID: 11095984 by Kaminski W.E., et al. Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene.