A1CF Antibodies

AND A1CF ELISA kits, A1CF Proteins

Many biological assays use antibodies to detect A1CF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with A1CF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop A1CF antibodies...

We validate the specificity of these antibodies to A1CF by testing them on tissues known to express A1CF positively and negatively. Browse below to find the A1CF antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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A1CF Infographic by Boster Bio

All A1CF Products

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A1CF (NM_138932) Human Recombinant Protein

$1062
Cat # PROTQ9NQ94
20 µg

A1CF (NM_138932) Human Over-expression Lysate

Human

$960
Cat # LS029974
100 µg

A1CF Overview

Facts about APOBEC1 complementation factor.

APOBEC1 complementation factor (A1CF)

Essential component of the apolipoprotein B mRNA editing enzyme complex that's responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is likely responsible for docking the catalytic subunit, APOBEC1, to the mRNA to let it deaminate its target cytosine.

The complex also protects the edited APOB mRNA from nonsense-mediated decay. .

Gene Information

Human
Gene Name:	A1CF
Uniprot:	Q9NQ94
Entrez:	29974

Family

Belongs to:

No superfamily

Alternative Names

ACF65; ACFASPACF64; apo-B RNA editing protein; apobec-1 complementation factor (ACF) (ASP); APOBEC1 complementation factor; APOBEC-1 stimulating protein; APOBEC1CF; APOBEC1-stimulating protein; MGC163391

Molecular Weight

Mass (kDA):
65.202 kDA

Genomic Context


Human

Location:	10q11.23
Sequence:	10; NC_000010.11 (50799409..50885675, complement)

Tissue Specificity

Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.

Subcellular Localizations

Nucleus. Endoplasmic reticulum. Cytoplasm. Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.

Diseases

Neoplasms
Liver Carcinoma
Dyslipidemias
Testicular Neoplasms
Hypothyroidism
Tumor Progression
Malignant Paraganglionic Neoplasm
Neoplasms, Germ Cell And Embryonal
Condylomata Acuminata
Carcinoma
Dysplasia

Congenital Hypothyroidism
Testicular Germ Cell Tumor
Kidney Diseases
Hyperlipidemia
Liver Neoplasms
Germ Cell Tumor

Interacting Proteins

CAVIN2
FHL3
REL
TRAF1

Pathways

Atp-dependent Chromatin Remodeling
Chromatin Remodeling
Translation
Cell Proliferation
Cell Differentiation
Triglyceride Mobilization
Mrna Processing
Interphase

Localization
Secretion

PTMs

Phosphorylation
Deamination

Decarboxylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/A1CF

References

PMID: 10781591 by Lellek H., et al. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex.

PMID: 10669759 by Mehta A., et al. Molecular cloning of APOBEC-1 complementation factor, a novel RNA- binding protein involved in the editing of apolipoprotein B mRNA.