Research Spotlight - September 2023

This month, we're excited to spotlight a selection of cutting-edge research studies that have benefited from Boster Bio's high-quality products.

Several studies this month deepen our understanding of disease mechanisms, including the role of pancreatic acinar cells in chronic pancreatitis fibrosis and the intriguing connections between the PCCB gene, associated with schizophrenia, and GABAergic pathways.

On the therapeutic front, different innovative methods have emerged, from an injectable hydrogel for osteoarthritis therapy to the promising rapid antidepressant-like effects of the connexin hemichannel inhibitor D4. Immunotherapy has also taken a front seat, with new research on IL2Rbg targeting combined with radiotherapy in HNSCC, and the screening of potential vaccines against Mycoplasma synoviae.

Scroll down to learn more and uncover insights from these new research studies!

Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells

Authors: Wang, D., Han, S., Lv, G., Hu, Y., Zhuo, W., Zeng, Z., Tang, J…
Journal: Gastroenterology

BACKGROUND AND AIMS: Studies have demonstrated that the activated pancreatic stellate cells (PSCs) play a crucial role in pancreatic fibrogenesis in chronic pancreatitis (CP), while the precise mechanism for PSCs activation has not been fully elucidated. We analyzed that the role of injured pancreatic acinar cells (iPACs)...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032)

Selective Targeting of IL2Rbg Combined With Radiotherapy Triggers CD8- and NK-Mediated Immunity, Abrogating Metastasis in HNSCC

Authors: Gadwa, J., Amann, M., Bickett, T.E., Knitz, M.W., Darragh, L.B…
Journal: Cell Reports Medicine

The implementation of cancer immunotherapies has seen limited clinical success in head and neck squamous cell carcinoma (HNSCC). Interleukin-2 (IL-2), which modulates the survival and functionality of lymphocytes, is an attractive target for new immunotherapies but one that is limited by presence of regulatory T cells (Tregs)...

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Cited Boster Product(s): Human IL-2/Interleukin-2 ELISA Kit PicoKine® (EK0397)

Human Forebrain Organoid-Based Multi-Omics Analyses of PCCB as a Schizophrenia Associated Gene Linked to GABAergic Pathways

Authors: Zhang, W., Zhang, M., Xu, Z., Yan, H., Wang, H., Jiang, J., Wan, J…
Journal: Nature Communications

Identifying genes whose expression is associated with schizophrenia (SCZ) risk by transcriptome-wide association studies (TWAS) facilitates downstream experimental studies. Here, we integrated multiple published datasets of TWAS, gene coexpression, and differential gene expression analysis to prioritize SCZ candidate genes for functional...

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Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1031)

Injectable Photocrosslinking Spherical Hydrogel-Encapsulated Targeting Peptide-Modified Engineered Exosomes for Osteoarthritis Therapy

Authors: Wan, J., He, Z., Peng, R., Wu, X., Zhu, Z., Cui, J., Hao, X., Chen, A…
Journal: Journal of Nanobiotechnology

Osteoarthritis (OA) is a common degenerative joint disease urgently needing effective treatments. Bone marrow mesenchymal stromal cell-derived exosomes (Exo) are considered good drug carriers whereas they have limitations such as fast clearance and low retention. This study aimed to overcome the limitations of Exo in drug delivery...

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Cited Boster Product(s): Anti-SOX9 Antibody Picoband™ (A00177-2); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032); RIPA Lysis Buffer (AR0105-100); Broad Spectrum Protease Inhibitor Cocktail (100x) (AR1182)

LncRNA DGCR5-Encoded Polypeptide RIP Aggravates SONFH by Repressing Nuclear Localization of b-catenin in BMSCs

Authors: Jiang, W., Chen, Y., Sun, M., Huang, X., Zhang, H., Fu, Z., Wang, J…
Journal: Cell Reports

The differentiation fate of bone marrow mesenchymal stem cells (BMSCs) affects the progression of steroid-induced osteonecrosis of the femoral head (SONFH). We find that lncRNA DGCR5 encodes a 102-amino acid polypeptide, RIP (Rac1 inactivated peptide), which promotes the adipogenic differentiation of BMSCs and aggravates the progression...

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Cited Boster Product(s): SDS-PAGE Protein Loading Buffer 5X (Reducing) (AR1112)

The Connexin Hemichannel Inhibitor D4 Produces Rapid Antidepressant-Like Effects in Mice

Authors: Li, H., Guo, A., Salgado, M., Sáez, J.C., Lau, C.G.
Journal: Journal of Neuroinflammation

Depression is a common mood disorder characterized by a range of clinical symptoms, including prolonged low mood and diminished interest. Although many clinical and animal studies have provided significant insights into the pathophysiology of depression, current treatment strategies are not sufficient to manage this disorder...

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Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394)

Exosomal PGAM1 Promotes Prostate Cancer Angiogenesis and Metastasis by Interacting With ACTG1

Authors: Luo, J.Q., Yang, T.W., Wu, J., Lai, H.H., Zou, L.B., Chen, W.B…
Journal: Cell Death & Disease

Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 in prostate cancer (PCa) metastasis remains unclear. In this study, we performed in vitro and in vivo to determine the functions...

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Cited Boster Product(s): 4% Paraformaldehyde (PFA) Solution In PBS (AR1068)

Screening of Immunogenic Proteins and Evaluation of Vaccine Candidates against Mycoplasma synoviae

Authors: Zhang, G., Han, L., Li, Z., Chen, Y., Li, Q., Wang, S., Shi, H.
Journal: npj Vaccines

Mycoplasma synoviae (M. synoviae) is a serious avian pathogen that causes significant economic losses to chicken and turkey producers worldwide. The currently available live attenuated and inactivated vaccines provide limited protection. The objective of this study was to identify potential subunit vaccine candidates using immunoproteomics...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); Anti-His Tag Antibody (Monoclonal, 9C11) (M30975); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050)

Fluoride-Induced Osteoporosis via Interfering With the RANKL/RANK/OPG Pathway in Ovariectomized Rats: Oophorectomy Shifted Skeletal Fluorosis From Osteosclerosis to Osteoporosis

Authors: Jin, Y., Zhou, B.H., Zhao, J., Ommati, M.M., Wang, S., Wang, H.W.
Journal: Environmental Pollution

Osteosclerosis and osteoporosis are the two main clinical manifestations of skeletal fluorosis. However, the reasons for the different clinical manifestations are unclear. In this study, we established the fluoride (F) -exposed ovariectomized (OVX) and non-OVX rat models to assess the potential role of ovarian function loss...

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Cited Boster Product(s): Anti-NFAT2/NFATC1 Antibody Picoband™ (A00340-1)

Actinidia Eriantha Polysaccharide Exerts Adjuvant Activity by Targeting linc-AAM

Authors: Xiong, B., Chen, X., Tu, J., Han, Z., Meng, X., Sun, H.
Journal: International Journal of Biological Macromolecules

Actinidia eriantha polysaccharide (AEPS) is a potent adjuvant with dual Th1 and Th2 potentiating activity. linc-AAM has been previously proved to facilitate the expression of immune response genes (IRGs) in AEPS-activated RAW264.7 macrophages. However, its role in mediating adjuvant activity of AEPS remains to be elucidated...

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Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527); Mouse IL-10/Interleukin-10 ELISA Kit PicoKine® (EK0417); Mouse CXCL10/IP-10 ELISA Kit PicoKine® (EK0736); Human MCP-1 / CCL2 ELISA Kit PicoKine® (EK0441)