Research Spotlight - October 2023

As autumn leaves turn golden, Boster Bio is excited to present a medley of pioneering studies that have recently been published. This month’s issue covers a spectrum from novel therapeutic interventions to insightful multi-omics analyses.

In the therapeutic domain, we spotlight a novel implantable hydrogel-based sensor that allows for real-time drug monitoring in rats. We also observe a shift in cancer treatments with a new cocktail nanovaccine. Additionally, fresh approaches are introduced for targeting lung fibrosis using mitochondrial transfer and enhancing liver cancer treatments with artesunate.

On a molecular scale, studies revealed how indoor air pollutants impact liver health and blood lipid levels. Scientists also investigated the protective role of gut fungi against intestinal issues and the potential of mung bean sprout nanoparticles in diabetes management. Moreover, recent findings linked a compound in the colon, phosphocholine, with a specific fungus Candida tropicalis, highlighting mycobiota’s importance for our digestive health.

Scroll down to learn more about these discoveries!

Implantable Hydrogel-Protective DNA Aptamer-Based Sensor Supports Accurate, Continuous Electrochemical Analysis of Drugs at Multiple Sites in Living Rats

Authors: Li, S., Dai, J., Zhu, M., Currás, N.A., Li, H., Wang, Y., Wang, Q…
Journal: ACS Nano

The ability to track the levels of specific molecules, such as drugs, metabolites, and biomarkers, in the living body, in real time and for long durations, would improve our understanding of health and our ability to diagnose, treat, and monitor disease. To this end, we are developing electrochemical aptamer-based (EAB) biosensors...

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Cited Boster Product(s): Rat IL-12(P70) ELISA Kit PicoKine® (EK1652); Rat Endothelin 1/EDN1 ELISA Kit PicoKine® (EK0952)

Efficient Intervention for Pulmonary Fibrosis via Mitochondrial Transfer Promoted by Mitochondrial Biogenesis

Authors: Huang, T., Lin, R., Su, Y., Sun, H., Zheng, X., Zhang, J., Lu, X…
Journal: Nature Communications

The use of exogenous mitochondria to replenish damaged mitochondria has been proposed as a strategy for the treatment of pulmonary fibrosis. However, the success of this strategy is partially restricted by the difficulty of supplying sufficient mitochondria to diseased cells. Herein, we report the generation of high-powered mesenchymal...

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Cited Boster Product(s): Mouse MMP-9 ELISA Kit PicoKine® (EK0466); Mouse TGF Beta 1 ELISA Kit PicoKine® (EK0515); 4% Paraformaldehyde (PFA) Solution In PBS (AR1068); Anti-Ki67/MKI67 Antibody Picoband™ (PB9026); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, FITC Conjugated (BA1105)

In Situ Cocktail Nanovaccine for Cancer Immunotherapy

Authors: Liu, M., Xie, D., Hu, D., Zhang, R., Wang Y., Tang, L., Zhou, B…
Journal: Advanced Science

In situ vaccination is a desirable strategy for cancer immunotherapy due to its convenience and capacity to target tumor antigens. Here, an in situ nanovaccine based on a cationic peptide with cholesterol-modified, DP7-C, for cancer immunotherapy is rationally designed, and developed a cancer nanovaccine that is easy to preparate...

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Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527)

Artesunate Sensitizes Human Hepatocellular Carcinoma to Sorafenib via Exacerbating AFAP1L2-SRC-FUNDC1 Axis-Dependent Mitophagy

Authors: Ma, Z., Chen, W., Liu, Y., Yu, L., Mao, X., Guo, X., Jiang, F., Guo, Q…
Journal: Autophagy

Sorafenib is the most widely used first-line drug for the treatment of the advanced hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance often limits its therapeutic efficacy. To evaluate the efficacy of artesunate against sorafenib-resistant HCC and to investigate its underlying pharmacological mechanisms...

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Cited Boster Product(s): Citrate Buffer Powder (AR0024)

Global Analysis of HLA-A2 Restricted MAGE-A3 Tumor Antigen Epitopes and Corresponding TCRs in Non-Small Cell Lung Cancer

Authors: Zhang, B., Ren, Z., Zhao, J., Zhu, Y., Huang, B., Xiao, C., Zhang, Y…
Journal : Theranostics

Background: Advanced non-small cell lung cancer (NSCLC) is the most common type of lung cancer with poor prognosis. Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. However, systematic...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054)

Multi-Omics Analysis Reveals Hepatic Lipid Metabolism Profiles and Serum Lipid Biomarkers Upon Indoor Relevant VOC Exposure

Authors: Miao, G., Wang, Y., Wang, B., Yu, H., Liu, J., Pan, R., Zhou, C…
Journal: Environment International

As a widespread indoor air pollutant, volatile organic compound (VOC) caused various adverse health effects, especial the damage to liver, which has become a growing public concern. However, the current toxic data are intrinsically restricted in the single or major VOC species. Limited knowledge is available regarding toxic effects...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)

LncRNA CCAT1 Facilitates the Progression of Gastric Cancer via PTBP1-Mediated Glycolysis Enhancement

Authors: Zhang, C., Wang, H., Liu, Q., Dai, S., Tian, G., Wei, X., Li, X., Zhao, L…
Journal: Journal of Experimental & Clinical Cancer Research

Background: Gastric cancer (GC) is one of the most prevalent malignant tumors of the digestive system. As a hallmark of cancer, energy-related metabolic reprogramming is manipulated by multiple factors, including long non-coding RNAs (lncRNAs). Notably, lncRNA CCAT1 has been identified as a crucial regulator in tumor progression...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, DyLight®488 Conjugated (BA1127)

Natural Exosomes-Like Nanoparticles in Mung Bean Sprouts Possesses Anti-Diabetic Effects via Activation of PI3K/Akt/GLUT4/GSK-3β Signaling Pathway

Authors: He, C., Wang, K., Xia, J., Qian, D., Guo, J., Zhong, L., Tang, D…
Journal: Journal of Nanobiotechnology

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia and insulin resistance. Mung bean sprouts are traditionally considered a “folk” hypoglycemic food and their pharmacological effects and underlying mechanisms warrant further investigation. Purpose: This study aimed to investigate...

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Cited Boster Product(s): SDS-PAGE Protein Loading Buffer 5X (Reducing) (AR1112); Plus RIPA Lysis Buffer (AR0102-100)

Enteric Fungi Protect Against Intestinal Ischemia–Reperfusion Injury via Inhibiting the SAA1-GSDMD Pathway

Authors: Chen, Y., Han, B., Guan, X., Du, G., Sheng, B., Tang, X., Zhang, Q…
Journal: Journal of Advanced Research

Introduction: Prophylactic antifungal therapy has been widely used for critical patients, but it has failed to improve patient prognosis and has become a hot topic. This may be related to disruption of fungal homeostasis, but the mechanism of fungi action is not clear. As a common pathway in critical patients, intestinal ischemia...

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Cited Boster Product(s): Mouse FABP2 ELISA Kit PicoKine® (EK1622)

Colonic Phosphocholine is Correlated With Candida tropicalis and Promotes Diarrhea and Pathogen Clearance

Authors: Zhou, X., He, Y., Chen, J., Xiong, X., Yin, J., Liang, J., Peng, C…
Journal: npj Biofilms and Microbiomes

Diarrhea is characterized by alterations in the gut microbiota, metabolites, and host response to these changes. Studies have focused on the role of commensal bacteria in diarrhea; however, the effect of fungi on its pathogenesis remains unexplored. Here, using post-weaned piglets with or without diarrhea, we found an unexpected...

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Cited Boster Product(s): Anti-DRA SLC26A3 Antibody (A03335)