Research Spotlight - November 2023

Welcome to this month’s Research Spotlight! In this issue, we are excited to showcase our customers’ new studies that are shaping the future of biomedicine.

In the field of neurology, researchers investigated a critical pathway, p300/NF-κB/NLRP3, impacted by disruptions in chaperone-mediated autophagy, which holds promise for treatments in neurodegenerative diseases. For regenerative medicine, scientists introduced a metal-organic framework-incorporated hydrogel that delivers neobavaisoflavone directly to damaged tissues, showing potential for osteoarthritis therapy.

In cancer research, scientists explored the epigenetic influence of the TP53 gene on prostate cancer's resistance to radiation, offering hope for more effective therapies. Researchers also delved into the use of antibody-opsonized nanoparticles to boost the immune response within tumors, potentially restraining melanoma metastasis.

For environmental research, scientists highlighted the connection between air pollution and bone health, while innovative nanoparticles open new doors for treating bone infections.

Scroll down to learn more about these discoveries!

Deficient Chaperone-Mediated Autophagy Facilitates LPS-Induced Microglial Activation via Regulation of the p300/NF-κB/NLRP3 Pathway

Authors: Wu, J., Han, Y., Xu, H., Sun, H., Wang, R., Ren, H., Wang, G.
Journal: Science Advances

Neuroinflammation is a pathological change that is involved in the progression of Parkinson’s disease. Dysfunction of chaperone-mediated autophagy (CMA) has proinflammatory effects. However, the mechanism by which CMA mediates inflammation and whether CMA affects microglia and microglia-mediated neuronal damage remain to be elucidated...

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Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411)

A Metal–Organic Framework-Incorporated Hydrogel for Delivery of Immunomodulatory Neobavaisoflavone to Promote Cartilage Regeneration in Osteoarthritis

Authors: Jiang, Y., Liao, H., Yan, L., Jiang, S., Zheng, Y., Zhang, X., Wang, K…
Journal: ACS Applied Materials & Interfaces

The treatment of osteoarthritis (OA)-related cartilage defects is a great clinical challenge due to the complex pathogenesis of OA and poor self-repair ability of cartilage tissue. Combining local and long-term anti-inflammatory therapies to promote cartilage repair is an effective method to treat OA. In this study, a zinc–organic...

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Cited Boster Product(s): Anti-CD68 (Macrophage Marker) Monoclonal Antibody (M00602)

Epigenetic Regulation of TP53 is Involved in Prostate Cancer Radioresistance and DNA Damage Response Signaling

Authors: Silva, C.M., Gonçalves, V.M., Tavares, N.T., Silva, D.B., Lencart, J…
Journal: Signal Transduction and Targeted Therapy

External beam radiotherapy (RT) is a leading first-line therapy for prostate cancer (PCa), and, in recent years, significant advances have been accomplished. However, RT resistance can arise and result in long-term recurrence or disease progression in the worst-case scenario. Thus, making crucial the discovery of new targets...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)

Reshaping Intratumoral Mononuclear Phagocytes with Antibody-Opsonized Immunometabolic Nanoparticles

Authors: Liu, C., Zhou, Y., Guo, D., Huang, Y., Ji, X., Li, Q., Chen, N., Fan, C...
Journal: Advanced Science

Mononuclear phagocytes (MPs) are vital components of host immune defenses against cancer. However, tumor-infiltrating MPs often present tolerogenic and pro-tumorigenic phenotypes via metabolic switching triggered by excessive lipid accumulation in solid tumors. Inspired by viral infection-mediated MP modulation, here enveloped...

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Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527); Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411)

Endothelial Deletion of EPH Receptor A4 Alters Single-Cell Profile and Tie2/Akap12 Signaling to Preserve Blood–Brain Barrier Integrity

Authors: Cash, A., de Jager, C., Brickler, T., Theus, M.H.
Journal: PNAS

Neurobiological consequences of traumatic brain injury (TBI) result from a complex interplay of secondary injury responses and sequela that mediates chronic disability. Endothelial cells are important regulators of the cerebrovascular response to TBI. Our work demonstrates that genetic deletion of endothelial cell (EC)-specific EPH...

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Cited Boster Product(s): Human Angiopoietin-2 / ANG2 ELISA Kit PicoKine® (EK0657)

Tumor Cell-Induced Platelet Aggregation Accelerates Hematogenous Metastasis of Malignant Melanoma by Triggering Macrophage Recruitment

Authors: Chen, Y., Zhou, J., Liu, Z., Wu, T., Li, S., Zhang, Y., Yin, X., Yang, G…
Journal: Journal of Experimental & Clinical Cancer Research

Background: Tumor cell-induced platelet aggregation (TCIPA) is not only a recognized mechanism for paraneoplastic thrombocytosis but also a potential breakthrough alternative for a low response to immune checkpoint inhibitors (ICIs) in hematogenous metastasis of malignant melanoma (MM). However, there is no TCIPA-specific model...

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Cited Boster Product(s): Mouse MCP-1 ELISA Kit PicoKine® (EK0568); Mouse IL-1 Alpha ELISA Kit PicoKine® (EK0391); Mouse IL-1 Beta ELISA Kit PicoKine® (EK0394); Mouse M-CSF ELISA Kit PicoKine® (EK0445); Mouse TGF Beta 1 ELISA Kit PicoKine® (EK0515); Mouse IFNG ELISA Kit PicoKine® (EK0375); Mouse IL-4 ELISA Kit PicoKine® (EK0405); Mouse IL-10 ELISA Kit PicoKine® (EK0417)

Ambient PM2.5 Exposure and Bone Homeostasis: Analysis of UK Biobank Data and Experimental Studies in Mice and in Vitro

Authors: Ge, Q., Yang, S., Qian, Y., Chen, J., Yuan, W., Li, S., Wang, P., Li, R…
Journal: Environmental Health Perspectives

Background: Previous evidence has identified exposure to fine ambient particulate matter (PM2.5) as a leading risk factor for adverse health outcomes. However, to date, only a few studies have examined the potential association between long-term exposure to PM2.5 and bone homeostasis. Objective: We sought to examine the relationship...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)

Targeting Neoadjuvant Chemotherapy-Induced Metabolic Reprogramming in Pancreatic Cancer Promotes Anti-Tumor Immunity and Chemo-Response

Authors: Tang, R., Xu, J., Wang, W., Meng, Q., Shao, C., Zhang, Y., Lei, Y…
Journal: Cell Reports: Medicine

The molecular dynamics of pancreatic ductal adenocarcinoma (PDAC) under chemotherapy remain incompletely understood. The widespread use of neoadjuvant chemotherapy (NAC) provides a unique opportunity to investigate PDAC samples post-chemotherapy. Leveraging a cohort from Fudan University Shanghai Cancer Center, encompassing PDAC...

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Cited Boster Product(s): Human IL-2/Interleukin-2 ELISA Kit PicoKine® (EK0397)

Unbiased Multitissue Transcriptomic Analysis Reveals Complex Neuroendocrine Regulatory Networks Mediated by Spinal Cord Injury-Induced Immunodeficiency

Authors: Zeng, H., Cheng, L., Lu, D.Z., Fan, S., Wang, K.X., Xu, L.L., Cai, B…
Journal: Journal of Neuroinflammation

Background: Spinal cord injury (SCI), which causes loss of sensory and motor function in the body below the level of injury, is a devastating disease of the central nervous system. SCI leads to severe secondary immunosuppression, called SCI-induced immunodeficiency syndrome (SCI-IDS), which is characterized by increased susceptibility...

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Cited Boster Product(s): Citrate Buffer Powder (AR0024)

Heterostructured Piezocatalytic Nanoparticles With Enhanced Ultrasound Response for Efficient Repair of Infectious Bone Defects

Authors: Lei, C., Lei, J., Zhang, X., Wang, H., He, Y., Zhang, W., Tong, B…
Journal: Acta Biomaterialia

Infection of bone defects remains a challenging issue in clinical practice, resulting in various complications. The current clinical treatments include antibiotic therapy and surgical debridement, which can cause drug-resistance and potential postoperative complications. Therefore, there is an urgent need for an efficient treatment...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160)