Research Spotlight - May 2023

We're delighted to present this month's research roundup, featuring studies from scientists we have served.

In this issue, dive into innovative cancer immunotherapy techniques using lipid rewiring nanoparticles to revitalize tumor-associated dendritic cells, uncover new mechanisms of antibiotic resistance in S. aureus, explore the potential of gut microbial b-galactosidase for alleviating liver damage, and examine the role of matrix stiffness in determining osteoclast fate.

Venture further into the intricacies of autophagy and its involvement in senescence due to mitotic errors. Researchers have also performed studies on cartilage regeneration, overcoming temozolomide resistance, and investigating the consequences of TREM2 deficiency in neuromyelitis optica spectrum disorder.

Scroll down to find out more. Stay curious and stay inspired!

Slimming and Reinvigorating Tumor-Associated Dendritic Cells with Hierarchical Lipid Rewiring Nanoparticles

Authors: Xu, C., Ji, X., Zhou, Y., Cheng, Y., Guo, D., Li, Q., Chen, N., Fan, C...
Journal: Advanced Materials

Dendritic cells (DCs) are crucial mediators of innate and adaptive anti-tumor immunity, whereas exogenously- and endogenously-driven lipid accumulation causes immune tolerance of tumor-associated DCs (TADCs) and thereby diminishes tumor responsiveness to various therapies. Herein, we design a type of multilevel lipid rewiring nanoparticles...

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Cited Boster Product(s): Mouse Granzyme B ELISA Kit PicoKine®; Mouse IL-12(P70) ELISA Kit PicoKine®; Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine®; Mouse IL-6/Interleukin-6 ELISA Kit PicoKine®

Transcription Tuned by S-nitrosylation Underlies a Mechanism for Staphylococcus aureus to Circumvent Vancomycin Killing

Authors: Shu, X., Shi, Y., Huang, Y., Yu, D., Sun, B.
Journal: Nature Communications

Treatment of Staphylococcus aureus infections is a constant challenge due to emerging resistance to vancomycin, a last-resort drug. S-nitrosylation, the covalent attachment of a nitric oxide (NO) group to a cysteine thiol, mediates redox-based signaling for eukaryotic cellular functions. However, its role in bacteria...

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Cited Boster Product(s): Anti-His Tag Antibody (Monoclonal, 9C11)

Liberation of Daidzein by Gut Microbial b-Galactosidase Suppresses Acetaminophen-Induced Hepatotoxicity in Mice

Authors: Zeng, Y., Wu, R., Wang, F., Li, S., Li, L., Li, Y., Qin, P., Wei, M…
Journal: Cell Host & Microbe

Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). The impact of the gut microbiota and associated metabolites on APAP and liver function remains unclear. We show that APAP disturbance is associated with a distinct gut microbial community, with notable decreases in Lactobacillus vaginalis...

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Cited Boster Product(s): Citrate Buffer Powder

Matrix Stiffness Regulates Osteoclast Fate Through Integrin-Dependent Mechanotransduction

Authors: Wang, X., Ji, L., Wang, J., Liu, C.
Journal: Bioactive Materials

Osteoclasts ubiquitously participate in bone homeostasis, and their aberration leads to bone diseases, such as osteoporosis. Current clinical strategies by biochemical signaling molecules often perturb innate bone metabolism owing to the uncontrolled management of osteoclasts. Thus, an alternative strategy of precise regulation...

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Cited Boster Product(s): Mouse Laminin ELISA Kit PicoKine®; Mouse Fibronectin ELISA Kit PicoKine®

Nuclear Translocation of cGAS Orchestrates VEGF-A-mediated Angiogenesis

Authors: Luo, J., Lu, C., Chen, Y., Wu, X., Zhu, C., Cui, W., Yu, S., Li, N…
Journal: Cell Reports

Cyclic GMP-AMP synthase (cGAS) senses cytosolic incoming DNA and consequently activates stimulator of interferon response cGAMP interactor 1 (STING) to mount immune response. Here, we show nuclear cGAS could regulate VEGF-A-mediated angiogenesis in an immune-independent manner. We found VEGF-A stimulation induces cGAS nuclear...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8)

The Establishment of Mitotic Errors-driven Senescence Depends on Autophagy

Authors: Goutas, A., Outskouni, Z., Papathanasiou, I., Georgakopoulou, A…
Journal: Redox Biology

We and others have reported that senescence onset is accompanied by genomic instability that is evident by several defects, such as aneuploidy or erroneous mitosis features. Here, we report that these defects also appear in young cells upon oxidative insult. We provide evidence that these errors could be the consequence of oxidative...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L)

Injectable and Degradable POSS–Polyphosphate–Polysaccharide Hybrid Hydrogel Scaffold for Cartilage Regeneration

Authors: Cui, L., Yang, Z., Hong, J., Zhu, Z., Wang, Z., Liu, Z., Zheng, W…
Journal: ACS Applied Materials & Interfaces

The limited self-repair capacity of articular cartilage has motivated the development of stem cell therapy based on artificial scaffolds that mimic the extracellular matrix (ECM) of cartilage tissue. In view of the specificity of articular cartilage, desirable tissue adhesiveness and stable mechanical properties under cyclic mechanical...

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Cited Boster Product(s): Human TGF-Beta 3 ELISA Kit PicoKine®

Aptamer-Functionalized Nanoplatforms Overcoming Temozolomide Resistance in Synergistic Chemo/Photothermal Therapy Through Alleviating Tumor Hypoxia

Authors: Zeng, Y., Zhao, L., Li, K., Ma, J., Chen, J., Chen, D., Liu, C., Zhan, W…
Journal: Nano Research

Tumor hypoxia is intimately associated with gliomas, which represent a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide (TMZ) due to hypoxia. In this work, to overcome TMZ resistance in orthotopic gliomas, aptamer-functionalized liposomes are manufactured to encapsulate TMZ...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining

TREM2 Deficiency Inhibits Microglial Activation and Aggravates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

Authors: You, Y.F., Chen, M., Tang, Y., Yu, W.X., Pang, X.W., Chu, Y.H…
Journal: Journal of Neuroinflammation

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are activated and play a pivotal role in response to tissue injury. Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed by microglia and promotes...

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Cited Boster Product(s): Nitrocellulose Membrane For Western Blot Transfer, Pore 0.45µm, Size 9cm X 10cm

MEX3B Inhibits Collagen Production in Eosinophilic Nasal Polyps by Downregulating Epithelial Cell TGFBR3 mRNA Stability

Authors: Liu, J.X., Nan, C.A., Yu, Q., Shi, K.T., Liu, Y.B., Guo, C.L…
Journal: JCI Insight

Although the expression of Mex3 RNA binding family member B (MEX3B) is upregulated in human nasal epithelial cells (HENCs) predominately in the eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) subtype, its functions as an RNA binding protein in airway epithelial cells remain unknown. Here, we revealed the role...

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Cited Boster Product(s): Human TGF Beta 1 ELISA Kit PicoKine®; Human TGF-Beta 2 ELISA Kit PicoKine®; Human TGF-Beta 3 ELISA Kit PicoKine®