Research Spotlight - June 2023

Welcome to the June issue of Research Spotlight! We are happy to feature 10 selected publications from scientists whom Boster has served.

Recent neurological research has uncovered the impact of glioblastoma on human neural circuits, providing insights into decreased survival. In oncology, researchers revealed the role of hepatic stellate cell stearoyl co-A desaturase in promoting liver tumorigenesis through the leukotriene B4 receptor 2 - β-catenin cascade.

Exciting advancements in biomedical techniques have also emerged. Scientists successfully alleviated chemotherapy-induced neuropathic pain using conditioned serum and exosomes. Single-cell RNA sequencing, nanoliposome-based thermosensitive hydrogels, and a protein domain-oriented approach have shed light on meningeal lymphatic dysfunction, osteoarthritis, and retinitis pigmentosa, respectively.

These scientific findings provide hope for improved treatments and therapies. Scroll down to find out more about the research studies!

Glioblastoma Remodelling of Human Neural Circuits Decreases Survival

Authors: Krishna, S., Choudhury, A., Keough, M.B., Seo, K., Ni, L…
Journal: Nature

Gliomas synaptically integrate into neural circuits. Previous research has demonstrated bidirectional interactions between neurons and glioma cells, with neuronal activity driving glioma growth and gliomas increasing neuronal excitability. Here we sought to determine how glioma-induced neuronal changes influence neural circuits…

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Cited Boster Product(s): Human THBS1/TSP1/Thrombospondin-1 ELISA Kit PicoKine® (EK0899)

Hepatic Stellate Cell Stearoyl co-A Desaturase Activates Leukotriene B4 Receptor 2 - β-Catenin Cascade to Promote Liver Tumorigenesis

Authors: Sinha, S., Aizawa, S., Nakano, Y., Rialdi, A., Choi, H.Y., Shrestha, R…
Journal: Nature Communications

Hepatocellular carcinoma (HCC) is the 3rd most deadly malignancy. Activated hepatic stellate cells (aHSC) give rise to cancer-associated fibroblasts in HCC and are considered a potential therapeutic target. Here we report that selective ablation of stearoyl CoA desaturase-2 (Scd2) in aHSC globally suppresses nuclear CTNNB1 and YAP1 in...

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Cited Boster Product(s): Anti-CYP1B1 Antibody Picoband™ (PB9546)

Intrathecal Administration of Conditioned Serum From Different Species Resolves Chemotherapy-Induced Neuropathic Pain in Mice via Secretory Exosomes

Authors: Buchheit, T., Huh, Y., Breglio, A., Bang, S., Xu, J., Matsuoka, Y…
Journal: Brain, Behavior, and Immunity

Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of chemotherapy for cancer, and has limited effective treatment options. Autologous conditioned serum (ACS) is an effective biologic therapy used by intra-articular injection for patients with osteoarthritis. However, ACS has not been…

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Cited Boster Product(s): Rat IL-10/Interleukin-10 ELISA Kit PicoKine® (EK0418); Rat TIMP-1 ELISA Kit PicoKine® (EK0583)

Single-Cell RNA Sequencing and Spatial Transcriptomics Reveal Pathogenesis of Meningeal Lymphatic Dysfunction after Experimental Subarachnoid Hemorrhage

Authors: Wang, X., Zhang, A., Yu, Q., Wang, Z., Wang, J., Xu, P., Liu, Y., Lu, J…
Journal: Advanced Science

Subarachnoid hemorrhage (SAH) is a devastating subtype of stroke with high mortality and disability rate. Meningeal lymphatic vessels (mLVs) are a newly discovered intracranial fluid transport system and are proven to drain extravasated erythrocytes from cerebrospinal fluid into deep cervical lymph nodes after SAH. However, many studies…

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Cited Boster Product(s): Human THBS1/TSP1/Thrombospondin-1 ELISA Kit PicoKine® (EK0899) ; Human TSP2/THBS2/Thrombospondin-2 ELISA Kit PicoKine® (EK0642)

PD-L1 Methylation Restricts PD-L1/PD-1 Interactions to Control Cancer Immune Surveillance

Authors: Huang, C., Ren, S., Chen, Y., Liu, A., Wu, Q., Jiang, T., Lv, P…
Journal: Science Advances

Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or programmed cell death 1 ligand 1 (PD-L1) have enabled some patients with cancer to experience durable, complete treatment responses; however, reliable anti–PD-(L)1 treatment response biomarkers are lacking. Our research found that PD-L1 K162 was methylated…

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Cited Boster Product(s): Cytoplasmic And Nuclear Protein Extraction Kit (AR0106)

Novel Strategy of Senescence Elimination via Toxicity-Exempted Kinome Perturbations by Nanoliposome-Based Thermosensitive Hydrogel for Osteoarthritis Therapy

Authors: Wan, J., He, Z., Zhao, Y., Hao, X., Cui, J., Chen, A., Zhou, J., Zhang, J.
Journal: Advanced Composites and Hybrid Materials

Cellular senescence and the senescence-associated secretory phenotype (SASP) have been implicated in osteoarthritis (OA). This study aims to determine whether multi-kinase inhibitor YKL-05-099 (Y099) has potential in senescence elimination and OA therapy and whether delivering Y099 by nanoliposmal hydrogel improves the performance of…

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Cited Boster Product(s): Anti-SOX9 Antibody Picoband™ (A00177-2)

Carbon Dots Induce Pathological Damage to the Intestine via Causing Intestinal Flora Dysbiosis and Intestinal Inflammation

Authors: Jia, M., Yi, B., Chen, X., Xu, Y., Xu, X., Wu, Z., Ji, J., Tang, J, Yu, D…
Journal: Journal of Nanobiotechnology

Background: Carbon dots (CDs), as excellent antibacterial nanomaterials, have gained great attention in treating infection-induced diseases such as periodontitis and stomatitis. Given the eventual exposure of CDs to the intestine, elucidating the effect of CDs on intestinal health is required for the safety evaluation of CDs. Results…

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Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527) ; Mouse IL-10/Interleukin-10 ELISA Kit PicoKine® (EK0417); Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine® (EK0375)

MTHFD2 Reprograms Macrophage Polarization by Inhibiting PTEN

Authors: Shang, M., Ni, L., Shan, X., Cui, Y., Hu, P., Ji, Z., Shen, L., Zhang, Y…
Journal: Cell Reports

The one-carbon metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is involved in the regulation of tumor oncogenesis and immune cell functions, but whether it can contribute to macrophage polarization remains elusive. Here, we show that MTHFD2 suppresses polarization of interferon-γ-activated macrophages (M(IFN-γ))...

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Cited Boster Product(s): Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse CCL22/MDC ELISA Kit PicoKine® (EK0447); Mouse CCL17/TARC ELISA Kit PicoKine® (EK0685)

Soluble CD80 Oral Delivery by Recombinant Lactococcus Suppresses Tumor Growth by Enhancing Antitumor Immunity

Authors: Lin, Z., Tang, Y., Chen, Z., Li, S., Xu, X., Hou, X., Chen, Z., Wen, J…
Journal: Bioengineering & Translational Medicine

CD80 is an important co-stimulatory molecule that participates in the immune response. Soluble CD80 can induce T cell activation and overcome PDL1-mediated immune suppression. In this study, we aimed to construct recombinant Lactococcus lactis for oral delivery of the soluble CD80 (hsCD80) protein or the fusion protein containing the…

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Cited Boster Product(s): Human B7-1/CD80 ELISA Kit PicoKine® (EK0707)

A Protein Domain-Oriented Approach to expand the Opportunities of Therapeutic exon Skipping for USH2A-Associated Retinitis Pigmentosa

Authors: Schellens, R.T.W., Broekman, S., Peters, T., Graave, P., Malinar, L…
Journal: Molecular Therapy: Nucleic Acids

Loss-of-function mutations in USH2A are among the most common causes of syndromic and non-syndromic retinitis pigmentosa (RP). We previously presented skipping of USH2A exon 13 as a promising treatment paradigm for USH2A-associated RP. However, RP-associated mutations are often private, and evenly distributed along the USH2A gene. In…

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Cited Boster Product(s): Anti-Zebrafish Ush2c/Adgrv1 C Terminus Antibody (DZ41033)