Research Spotlight - December 2023

Welcome to the latest issue of Research Spotlight! We're excited to dive into biomedical breakthroughs that are impacting health and disease research.

In the field of neuroscience, research revealed how stress affects the brain, particularly the red nucleus, and its link to anxiety and immune responses. This insight has implications for treating mental health disorders. In respiratory research, a new study advanced our understanding of how the lungs detect allergens, opening up possibilities for better treatments for respiratory diseases.

For regenerative medicine, scientists demonstrated that iron deficiency hampers muscle healing through specific molecular pathways, paving the way for improved muscle repair treatments.

Biologists also investigated SMURF1 protein's role in cell waste management and renewal, offering insights into maintaining cell health. Lastly, researchers proposed innovative use of stem cell-derived mitochondria, potentially enhancing treatments for nerve damage recovery.

Scroll down to find out more about these exciting discoveries!

Stress-induced Red Nucleus Attenuation Induces Anxiety-like Behavior and Lymph Node CCL5 Secretion

Authors: Shi, D.D., Zhang, Y.D., Zhang, S., Liao, B.B., Chu, M.Y., Su, S…
Journal: Nature Communications

Previous studies have speculated that brain activity directly controls immune responses in lymphoid organs. However, the upstream brain regions that control lymphoid organs and how they interface with lymphoid organs to produce stress-induced anxiety-like behavior remain elusive. Using stressed human participants and rat models...

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Cited Boster Product(s): Rat Rantes ELISA Kit PicoKine® (EK0496)

Cholinergic Sensing of Allergen Exposure by Airway Epithelium Promotes Type 2 Immunity in the Lungs

Authors: Hayashi, R., Srisomboon, Y., Iijima, K., Maniak, P.J., Tei, R…
Journal: Journal of Allergy and Clinical Immunology

Non-neuronal cells, including epithelial cells, can produce acetylcholine (ACh). Muscarinic ACh receptor antagonists are used clinically to treat asthma and other medical conditions; however, knowledge regarding the roles of ACh in type 2 immunity is limited. Objective: To investigate the roles of epithelial ACh in allergic...

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Cited Boster Product(s): Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 Antibody (A04081)

Iron Deficiency–induced Ferritinophagy Impairs Skeletal Muscle Regeneration Through RNF20-mediated H2Bub1 Modification

Authors: Che, Y., Li, J., Wang, P., Yu, W., Lin, J., Su, Z., Ye, F., Zhang, Z…
Journal: Science Advances

Iron deficiency (ID) is a widespread condition concomitant with disease and results in systemic dysfunction of target tissues including skeletal muscle. Activated by ID, ferritinophagy is a recently found type of selective autophagy, which plays an important role in various physiological and pathological conditions. In this study...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050)

SMURF1 Controls the PPP3/Calcineurin Complex and TFEB at a Regulatory Node for Lysosomal Biogenesis

Authors: Xia, Q., Zheng, H., Li, Y., Xu, W., Wu, C., Xu, J., Li, S., Zhang, L…
Journal: Autophagy

Macroautophagy/autophagy is a homeostatic process in response to multiple signaling, such as the lysosome-dependent recycling process of cellular components. Starvation-induced MTOR inactivation and PPP3/calcineurin activation were shown to promote the nuclear translocation of TFEB. However, the mechanisms via which signals...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050); HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Rabbit Anti-Rat IgG (H+L) (BA1058)

Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy

Authors: Hu, J., You, Y., Zhu, L., Zhang, J., Song, Y., Lu, J., Xu, X., Wu, X…
Journal: Small

The efficacy of immune checkpoint blockade (ICB) in promoting an immune response against tumors still encounters challenges such as low response rates and off-target effects. Pyroptosis, an immunogenic cell death (ICD) mechanism, holds the potential to overcome the limitations of ICB by activating and recruiting immune cells...

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Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394)

Estradiol-mediated Small GTP-binding Protein GDP Dissociation Stimulator Induction Contributes to Sex Differences in Resilience to Ferroptosis in Takotsubo Syndrome

Authors: Wang, T., Xiong, T., Yang, Y., Chen, X., Ma, Z., Zuo, B., Ning, D…
Journal: Redox Biology

Background: Declining beneficial cardiovascular actions of estradiol (E2) have been associated with disproportionate susceptibility to takotsubo syndrome (TTS) in postmenopausal women. However, the underlying mechanisms between E2 and this marked disproportion remain unclear. SmgGDS (small GTP-binding protein GDP dissociation stimulator...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, FITC Conjugated (BA1105); Goat Anti-Mouse IgG (H+L) Secondary Antibody, DyLight®594 Conjugated (BA1141)

Mesenchymal Stem Cell-Derived Mitochondria Enhance Extracellular Matrix-Derived Grafts for the Repair of Nerve Defect

Authors: Bai, J., Yu, B., Li, C., Cheng, H., Guan, Y., Ren, Z., Zhang, T…
Journal: Advanced Healthcare Materials

Peripheral nerve injuries (PNI) can lead to mitochondrial dysfunction and energy depletion within the affected microenvironment. The objective is to investigate the potential of transplanting mitochondria to reshape the neural regeneration microenvironment. High-purity functional mitochondria with an intact structure are extracted...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)

An Intronic Enhancer of Cebpa Regulates Adipocyte Differentiation and Adipose Tissue Development via Long-range Loop Formation

Authors: Li, X., Zeng, S., Chen, L., Zhang, Y., Li, X., Zhang, B., Su, D., Du, Q…
Journal: Cell Proliferation

Cebpa is a master transcription factor gene for adipogenesis. However, the mechanisms of enhancer–promoter chromatin interactions controlling Cebpa transcriptional regulation during adipogenic differentiation remain largely unknown. To reveal how the three-dimensional structure of Cebpa changes during adipogenesis...

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Cited Boster Product(s): Anti-CEBP Alpha/CEBPA Antibody Picoband™ (A00386-1); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, TRITC Conjugated (BA1090); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, DyLight®488 Conjugated (BA1127)

Ultrasonic Neural Regulation Over Two-dimensional Graphene Analog Biomaterials: Enhanced PC12 Cell Differentiation Under Diverse Ultrasond Excitation

Authors: Zhao, H., Cao, Z., Sun, D., Chen, X., Kang, S., Zheng, Y., Sun, D.
Journal: Ultrasonics Sonochemistry

Two-dimensional (2D) biomaterials, with unique planar topology and quantum effect, have been widely recognized as a versatile nanoplatform for bioimaging, drug delivery and tissue engineering. However, during the complex application of nerve repair, in which inflammatory microenvironment control is imperative, the gentle manipulation...

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Cited Boster Product(s): Rat NGF/NGF Beta ELISA Kit PicoKine® (EK0471); Rat BDNF ELISA Kit PicoKine® (EK0308)

Injectable Hydrogel With Selenium Nanoparticles Delivery for Sustained Glutathione Peroxidase Activation and Enhanced Osteoarthritis Therapeutics

Authors: Hu, W., Yao, X., Li, Y., Li, J., Zhang, J., Zou, Z., Kang, F., Dong, S.
Journal: Materials Today Bio

Reactive oxygen burst in articular chondrocytes is a major contributor to osteoarthritis progression. Although selenium is indispensable role in the antioxidant process, the narrow therapeutic window, delicate toxicity margins, and lack of an efficient delivery system have hindered its translation to clinical applications...

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Cited Boster Product(s): Anti-GPX1 Antibody Picoband™ (Monoclonal, 8B10) (M01019-2)