Research Spotlight - April 2023

For our April issue of Research Spotlight, we’re happy to feature 10 recent publications from scientists whom Boster has served.

In one study, to prevent cardiac fibrosis after myocardial infarction (MI), researchers developed a reduced glutathione (GSH)-responsive nanoparticle platform for targeted drug delivery to activated cardiac fibroblasts (CFs) within the infarct area of a post-MI heart, which demonstrated higher therapeutic efficacy and lower systemic toxicity than systemic drug administration.

Another study investigated the osteo-immunomodulatory effects of bicalcium phosphate (BCP) ceramics coupled with micro-vibration stimulation (MVS). Our selected papers also include studies on bacterial outer membrane vesicles (OMVs) for intestinal homeostasis regulation, 3TC for protection against age-related cognitive dysfunction, and several more.

Scroll down to learn about exciting discoveries from top scientific journals!

Cysteine-Based Redox-Responsive Nanoparticles for Fibroblast-Targeted Drug Delivery in the Treatment of Myocardial Infarction

Authors: Ji, X., Meng, Y., Wang, Q., Tong, T., Liu, Z., Lin, J., Li, B., Wei, Y…
Journal: ACS Nano

Upon myocardial infarction (MI), activated cardiac fibroblasts (CFs) begin to remodel the myocardium, leading to cardiac fibrosis and even heart failure. No therapeutic approaches are currently available to prevent the development of MI-induced pathological fibrosis. Most pharmacological trials fail from poor local drug activity...

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Cited Boster Product(s): Anti-ACTA2/Alpha Smooth Muscle Actin Monoclonal Antibody (A01072)

Versatility of Bacterial Outer Membrane Vesicles in Regulating Intestinal Homeostasis

Authors: Wang, X., Lin, X., Wang, L., Cao, Z., Zhang, M., Zhang, Y., Liu, R...
Journal: Science Advances

Outer membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota–derived OMVs in the intestine remain poorly understood. Here, we report that OMVs released from Akkermansia muciniphila are able to (i) restore disturbed...

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Cited Boster Product(s): Mouse ACE2 ELISA Kit PicoKine® (EK1188)

Coupling BCP Ceramics with Micro-Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration

Authors: Wu, J., Wang, M., Wu, Y., Liu, J., Zhi, W., Chen, X., Zhu, X., Zhang, X.
Journal: Advanced Functional Materials

The osteoimmunology has revealed that immune system plays an important role in maintaining bone metabolism and remodeling. As long-term physiological factor in bone, mechanical stimulation such as micro-vibration stimulation (MVS) exerts effects on regulating osteogenesis and immune response. In this study, the osteo-immunodulatory...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)

The Rhythmic Coupling of Egr-1 and Cidea Regulates Age-Related Metabolic Dysfunction in the Liver of Male Mice

Authors: Wu, J., Bu, D., Wang, H., Shen, D., Chong, D., Zhang, T., Tao, W…
Journal: Nature Communications

The liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm of genes involved in lipid metabolism is also disturbed. Although the link between metabolism and circadian rhythms is already recognized, how these processes are decoupled in liver during aging is still largely unknown...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050)

The Reverse Transcriptase Inhibitor 3TC Protects Against Age-Related Cognitive Dysfunction

Authors: Wahl, D., Smith, M.E., McEntee, C.M., Cavalier, A.N., Osburn, S.C…
Journal: Aging Cell

Aging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease. Major hallmarks of brain aging include neuroinflammation/immune activation and reduced neuronal health/function. These processes contribute to cognitive dysfunction (a key risk factor for Alzheimer's disease)...

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Cited Boster Product(s): Multiplex ELISA Kit For Mouse Cytokine Panel 2 (4-Plex) (MEK1016)

Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation

Authors: Wang, S., Tian, Z., Lu, Y., Huang, Z., Fan, Y., Li, B., Zheng, H., Wu, X…
Journal: International Journal of Biological Sciences

Patients with eosinophilic asthma react well to conventional treatment of asthma while individualized therapy for non-eosinophilic endotypes have yet to be developed. Dysregulated sphingosine metabolites are associated with the pathophysiology of different asthma endotypes with their receptors involved. However, whether the sphingosine...

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Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411); Mouse IL-12(P40) ELISA Kit PicoKine® (EK0932)

Macrophage-Derived Exosomes Mediate Glomerular Endothelial Cell Dysfunction in Sepsis-Associated Acute Kidney Injury

Authors: Xiang, H., Xu, Z., Zhang, C., Xiong, J.
Journal: Cell & Bioscience

Background: Sepsis-associated AKI has been shown to be related to sepsis mortality. Macrophage activation and endothelial cell damage are involved in the progression of sepsis-associated AKI, but the specific mechanisms are still unclear. Methods: In vitro experiments, exosomes extracted from lipopolysaccharide (LPS) -stimulated...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160)

Airway Delivery of Streptococcus salivarius is Sufficient to Induce Experimental Pulmonary Hypertension in Rat

Authors: Zhang, C., Zhang, T., Xing, Y., Lu, W., Chen, J., Luo, X., Wu, X…
Journal: British Journal of Pharmacology

Background and purpose: The causal relationship between altered host microbiome composition, especially the respiratory tract microbiome, and the occurrence of pulmonary hypertension (PH) has not yet been studied. An increased abundance of airway streptococci is seen in patients with PH compared with healthy individuals...

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Cited Boster Product(s): Anti-CD68 (Macrophage Marker) Monoclonal Antibody (M00602)

Metal-Mediated Nanobody Assemblies as Potent Alleviators of Human Islet Amyloid Polypeptide Aggregation

Authors: Zhao, L., Luo, L., Meng, F.
Journal: Materials Chemistry Frontiers

The misfolding and aggregation of peptides and proteins into β-sheet-enriched amyloid fibrils has been implicated in many human diseases. Inhibition of protein aggregation by engineered nanobodies has shown great promise in the treatment of amyloid-associated diseases. Taking type 2 diabetes associated human islet amyloid polypeptide...

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Cited Boster Product(s): HRP Conjugated Streptavidin (BA1088)

Isoforsythiaside Confers Neuroprotection Against Alzheimer’s Disease by Attenuating Ferroptosis and Neuroinflammation in vivo and in vitro

Authors: Wang, C., Jiang, H., Liu, H., Chen, S., Guo, H., Ma, S., Han, W…
Journal: Food Science and Human Wellness

Ferroptosis and neuroinflammation contribute to the development of Alzheimer's disease (AD). Isoforsythiaside (IFY) is a phenylethanoid glycoside isolated from the dried fruit of Forsythia suspensa (Thunb.) Vahl that has been confirmed to improve the memory and cognitive abilities of APP/PS1 mice in our previous study...

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Cited Boster Product(s): Anti-GFAP Antibody Picoband™ (PB9082); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Biotin Conjugated (BA1003); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411)