This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
NTRK2 Antibodies
AND NTRK2 ELISA kits, NTRK2 Proteins
Many biological assays use antibodies to detect NTRK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NTRK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NTRK2 antibodies...
Previous: CBLIF
Next: NTS
NTRK2 Infographic by Boster Bio
All NTRK2 Products
Product
Figures
Specificity
Applications
Price
Mouse TrkB ELISA Kit PicoKine®
2 Citations 4 Q&As
Mouse
ELISA
$499
Cat # EK0849
96 wells/kit, with removable strips.
Cat # EK0849
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK0848
96 wells/kit, with removable strips.
Cat # EK0848
96 wells/kit, with removable strips.
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # P01388
100 μl
Cat # P01388
100 μl
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$405
Cat # A01388Y817
100ul
Cat # A01388Y817
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01388Y706-1
100ul
Cat # A01388Y706-1
100ul
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M01388-1
100 µl
Cat # M01388-1
100 µl
Anti-TrkB Rabbit Monoclonal Antibody
1 Citations
Mouse, Rat
IP, IHC, WB
$370
Cat # M01388-3
100 μl/vial
Cat # M01388-3
100 μl/vial
NTRK2 Overview
Facts about BDNF/NT-3 growth factors receptor.
BDNF/NT-3 growth factors receptor (NTRK2)
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Alternatively can also bind NTF3/neurotrophin-3 that is less effective in activating the receptor but regulates neuron survival through NTRK2.
Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that govern distinct overlapping signaling cascades.
Gene Information
| Human | |
|---|---|
| Gene Name: | NTRK2 |
| Uniprot: | Q16620 |
| Entrez: | 4915 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
BDNF/NT-3 growth factors receptor; EC 2.7.10; EC 2.7.10.1; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; NTRK2; TrkB tyrosine kinase; TrkB; trk-B; TRKBBDNF-tropomyosine receptor kinase B; tyrosine kinase receptor B
Molecular Weight
Mass (kDA):
91.999 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q21.33 |
| Sequence: | 9; NC_000009.12 (84668458..85027070) |
Tissue Specificity
Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Cell junction, synapse, postsynaptic density. Internalized to endosomes upon ligand-binding.
Diseases
- Nervousness
- Neoplasms
- Depressive Disorder
- Malignant Neoplasms
- Major Depressive Disorder
- Carcinoma
- Cancer Patients And Suicide And Depression
- Neuroblastoma
- Dysequilibrium Syndrome
- Mental Disorders
- Bipolar Disorder
- Cell Invasion
Interacting Proteins
- Cdk5
- NTF4
Pathways
- Pathogenesis
- Cell Proliferation
- Localization
- Neurogenesis
- Innervation
- Cell Cycle
- Cell Death
- Angiogenesis
- Cell Adhesion
- Cell Migration
- Epithelial To Mesenchymal Transition
- Regeneration
- Transport
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NTRK2
bosterbio.com/bosterbio-gene-info-cards/NTRK2
References
PMID: 7789988 by Nakagawara A., et al. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2).
PMID: 7823156 by Shelton D.L., et al. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.
5 Publications of Boster NTRK2 Antibodies & ELISA Kits
- PubMed ID: 10.1080/09637486.2019.1681380, Degree of lipid saturation affects depressive-like behaviour and gut microbiota ...
- PubMed ID: 10.1002/cbf.3283, Differential expression of microRNAs in TM3 Leydig cells of mice treated with br...
- PubMed ID: , Inhibition of colony stimulating factor 1 receptor corrects maternal inflammatio...
- PubMed ID: 28116298, 7,8-DHF Treatment Induces Cyr61 Expression to Suppress Hypoxia Induced ER Stress...
- PubMed ID: 25730461, Effects of senescence on the expression of BDNF and TrkB receptor in the lateral...
*More publications can be found for each product on its corresponding product page