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Key=sku, value=P04629
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Key=required_options, value=1
Key=created_at, value=2016-12-15 06:48:24
Key=updated_at, value=2024-10-27 05:01:30
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-Phospho-Potassium Chloride Cotransporter 2 (KCC2) (Ser940) SLC12A5 Antibody
Key=cj_search_index
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Key=is_recurring, value=No
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Key=featured, value=No
Key=featured_image, value=Yes
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Key=free_shipping, value=No
Key=template, value=antibodies
Key=host, value=Rabbit
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Key=price, value=481.0000
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Key=meta_title, value=Anti-Phospho-Potassium Chloride Cotransporter 2 (KCC2) (Ser940) SLC12A5 Antibody
Key=meta_description, value=Boster Bio Anti-Phospho-Potassium Chloride Cotransporter 2 (KCC2) (Ser940) SLC12A5 Antibody (Catalog # P04629). Tested in WB, IP applications. This antibody reacts with Mouse, Rat. Supplied as 100 µl in Liquid form antibody.
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Key=thumbnail, value=/P/0/P04629-Western_blot-testing-image-1.gif
Key=url_key, value=anti-potassium-chloride-cotransporter-2-kcc2-ser940-antibody-phospho-specific-p04629-boster
Key=url_path, value=anti-potassium-chloride-cotransporter-2-kcc2-ser940-antibody-phospho-specific-p04629-boster
Key=options_container, value=Product Info Column
Key=image_label, value=Western blot of rat hippocampal lysate showing specific labeling of the ~135 kDa KCC2 protein phosphorylated at Ser⁹⁴⁰ in the first lane (-). Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen in the second lane
Key=small_image_label, value=Western blot of rat hippocampal lysate showing specific labeling of the ~135 kDa KCC2 protein phosphorylated at Ser⁹⁴⁰ in the first lane (-). Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen in the second lane
Key=thumbnail_label, value=Western blot of rat hippocampal lysate showing specific labeling of the ~135 kDa KCC2 protein phosphorylated at Ser⁹⁴⁰ in the first lane (-). Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen in the second lane
Key=msrp_display_actual_price_type, value=
Key=gift_message_available, value=No
Key=size, value=100 µl
Key=protein_name, value=Solute carrier family 12 member 5
Key=gene_full_name, value=Solute carrier family 12 member 5
Key=uniprot_id, value=Q63633
Key=applications, value=IP, WB
Key=reactivity, value=Mouse, Rat
Key=form, value=Liquid
Key=concentration, value=0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Key=cross_reactivity, value=No cross reactivity with other proteins.
Key=clone_number
Key=predicted_reactivity, value=Bovine, Canine, Primate, Zebrafish
Key=source_company, value=Phosphosolutions p1551-940; Cost: 267
Key=isotype, value=IgG
Key=molecular_weight, value=126184 MW
Key=sample_size_available, value=5ul, free with shipping charge
Key=related_product_skus, value=A04133
Key=product_category, value=Primary Antibodies
Key=research_category, value=Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels
Key=clonality, value=Polyclonal
Key=swatch_image, value=/antibody/ek1221-2-ELISA-human-soluble-cd6-picokine-elisa-kit.jpg
Key=rating_value, value=97.9
Key=review_count, value=7
Key=phospho_site, value=Phosphorylated, Ser940
Key=mp_exclude_sitemap, value=No
Key=yoast_facebook_image, value=/a/1/a13384-western-blotting-analysis-1.jpg
Key=yoast_twitter_image, value=/a/1/a13384-western-blotting-analysis-1.jpg
Key=cj_related_products, value=Columnar Cell Change Of The Breast:A03490|M03490^Gitelman Syndrome:A02516-3^Ion Transport:PROTQ9NP86^Spinal Cord Injuries:A01761-1
Key=description, value=Boster Bio Anti-Phospho-Potassium Chloride Cotransporter 2 (KCC2) (Ser940) SLC12A5 Antibody (Catalog # P04629). Tested in WB, IP applications. This antibody reacts with Mouse, Rat.
Key=short_description, value=Boster Bio Anti-Phospho-Potassium Chloride Cotransporter 2 (KCC2) (Ser940) SLC12A5 Antibody (Catalog # P04629). Tested in WB, IP applications. This antibody reacts with Mouse, Rat.
Key=meta_keyword, value=Anti-Phospho-Potassium Chloride Cotransporter 2 (KCC2) (Ser940) SLC12A5 Antibody
Key=contents, value=10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Key=background, value=KCC2 is widely thought to be expressed exclusively in neurons where it is responsible for maintaining low intracellular chloride concentration to drive hyperpolarizing post-synaptic responses to the inhibitory neurotransmitters GABA and glycine. Serine 940 on KCC2 has been shown to be phosphorylated by PKC and has further been demonstrated to be the major site for PKC-dependent phosphorylation for full length KCC2 molecules when expressed in HEK-293 cells as phosphorylation of Ser-940 increased the cell surface stability of KCC2 in this system by decreasing it’s rate of internalization from the plasma membrane (Lee et al., 2007).
Key=gene_name, value=KCC2
Key=synonyms, value=Electroneutral potassium chloride cotransporter 2 antibody, Electroneutral potassium-chloride cotransporter 2 antibody, Erythroid K Cl cotransporter 2 antibody, Furosemide sensitive K Cl cotransporter antibody, hKCC2 antibody, K-Cl cotransporter 2 antibody, KCC 2 antibody, KCC2 antibody, KIAA1176 antibody, Neuronal K Cl cotransporter antibody, Neuronal K-Cl cotransporter antibody, Potassium Chloride Cotransporter antibody, Potassium chloride transporter 5 antibody, rKCC2 antibody, S12A5 antibody, S12A5_HUMAN antibody, SLC12A5 antibody, Solute carrier family 12 (potassium chloride transporter) member 5 antibody, Solute carrier family 12 member 5 antibody
Key=application_details, value=WB: 1:1000
IP: 40ul of antibody per 1mg lysate
Key=subcellular_localization, value= Membrane; Multi-pass membrane protein.
Key=tissue_specificity, value= Brain specific. Detected in neuronal cells.
Key=protein_function, value= Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl (-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl (-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).
Key=application_notes, value=Specific for endogenous levels of the ~135 kDa KCC2 protein phosphorylated at Ser940. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.
Key=competitor_equivalent_skus, value=sc 6454|sc 6455|sc 100777|sc 6453
Key=immunogen, value=Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser940 of rat KCC2, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.
Key=purification, value=Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
Key=storage, value=Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
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