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Product Info Summary
| SKU: | A07242 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-NOD3 NLRC3 Antibody
SKU/Catalog Number
A07242
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NOD3 NLRC3 Antibody (Catalog # A07242). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
NOD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NOD3 NLRC3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07242)
Host
Rabbit
Contents
NOD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3. The immunogen is located within amino acids 630 - 680 of NOD3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TTYH1 antibody is human specific. Multiple isoforms of TTYH1 are known to exist.
Reactive Species
A07242 is reactive to NLRC3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
114658 MW
Background of NLRC3
NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07242 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NOD3 antibody can be used for detection of NOD3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of NOD3 in 3T3 cell lysate with NOD3 antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of NOD3 in Jurkat cells with NOD3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NLRC3 (Source: Uniprot.org, NCBI)
Gene Name
NLRC3
Full Name
NLR family CARD domain-containing protein 3
Weight
114658 MW
Superfamily
NLRP family
Alternative Names
NOD3, CLR16.2, NOD3, Protein NLRC3, CARD15-like protein NLRC3 CLR16.2, NOD3 NLR family CARD domain containing 3 NLR family CARD domain-containing protein 3|CARD15-like protein|NACHT, LRR and CARD domains-containing protein 3|NOD-like receptor C3|caterpiller protein 16.2|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NLRC3, check out the NLRC3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NLRC3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NOD3 NLRC3 Antibody (A07242)
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