Anti-NIK MAP3K14 Antibody

Product Name

Anti-NIK MAP3K14 Antibody

View all NIK/MAP3K14 Antibodies

SKU/Catalog Number

A03822

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-NIK MAP3K14 Antibody (Catalog # A03822). Tested in ELISA, WB, IF, ICC applications. This antibody reacts with Human.

Storage & Handling

NIK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-NIK MAP3K14 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03822)

Host

Rabbit

Contents

NIK Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

NIK antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NIK. The immunogen is located within the last 50 amino acids of NIK.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

DEPTOR antibody is human, mouse and rat reactive. At least three isoforms of DEPTOR are known to exist; this antibody will detect all three isoforms.

Reactive Species

A03822 is reactive to MAP3K14 in Human

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

104042 MW

Background of NIK/MAP3K14

Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, LPS and mitogens. A serine/threonine protein kinase which mediates NF-κB activation by IL-1, TNFα and CD95 was identified recently and designated NIK (for NF-κB inducing kinase). NIK is an activator of IκB kinase alpha and beta (IKKα and IKKβ). Therefore, NIK is a key molecule in the NF-κB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A03822 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

NIK antibody can be used for detection of NIK by Western blot at 1 - 2 μg/mL.
Antibody validated: Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For MAP3K14 (Source: Uniprot.org, NCBI)

Alternative Names

HS, NIK, HSNIK, FTDCR1B, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK MAP3K14 FTDCR1B, HS, HSNIK, NIK mitogen-activated protein kinase kinase kinase 14 mitogen-activated protein kinase kinase kinase 14|NF-kappa-beta-inducing kinase|serine/threonine-protein kinase NIK

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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