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- Table of Contents
38 Citations 16 Q&As
172 Citations 8 Q&As
Facts about Interleukin-8.
It's released from several cell types in response to an inflammatory stimulus. IL-8(6-77) includes a 5-10-fold higher action on neutrophil activation, IL-8(5-77) has increased action on neutrophil activation and IL-8(7-77) has a greater affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Human | |
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Gene Name: | CXCL8 |
Uniprot: | P10145 |
Entrez: | 3576 |
Belongs to: |
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intercrine alpha (chemokine CxC) family |
3-10C; AMCF-I; C-X-C motif chemokine 8; CXCL8; CXCL8SCYB8; Emoctakin; GCP1; GCP-1TSG-1; IL8; IL-8; interleukin 8; K60; LAI; LECT; LUCT; LYNAP; MDNCF; MDNCFb-ENAP; member 8; MONAP; MONAPGCP1; NAF; NAP1; NAP-1NAP1; NCF; Neutrophil-activating protein 1; Protein 3-10C; T cell chemotactic factor; T-cell chemotactic factor; TCF; TSG1
Mass (kDA):
11.098 kDA
Human | |
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Location: | 4q13.3 |
Sequence: | 4; NC_000004.12 (73740569..73743716) |
Secreted.
PMID: 2953813 by Schmid J., et al. Induction of mRNA for a serine protease and a beta-thromboglobulin- like protein in mitogen-stimulated human leukocytes.
PMID: 3260265 by Matsushima K., et al. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.
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