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Product Info Summary
| SKU: | FC00570-Biotin |
|---|---|
| Size: | 100ug |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry |
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Product info
Product Name
Anti-human CD2 Monoclonal Antibody Biotin Conjugated, Flow Validated
SKU/Catalog Number
FC00570-Biotin
Size
100ug
Form
Liquid
Description
Boster Bio Anti-human CD2 Monoclonal Antibody Biotin Conjugated, Flow Validated (Catalog# FC00570-Biotin). Tested in Flow Cytometry application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-human CD2 Monoclonal Antibody Biotin Conjugated, Flow Validated (Boster Biological Technology, Pleasanton CA, USA, Catalog # FC00570-Biotin)
Host
Mouse
Contents
#N/A
Clonality
Monoclonal
Clone Number
Clone: OKT11
Isotype
IgG1,k
Immunogen
Human acute lymphoblastic leukemia cells
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
FC00570-Biotin is reactive to CD2 in Human
Reconstitution
Calculated molecular weight
39448 MW
Background of CD2
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portionThe localization of CD2 to 1p13 was established by in situ hybridization. By Southern blotting of DNA from a panel of somatic cell hybrids, Clayton et al. (1988) assigned the CD2 gene to human chromosome 1 and murine chromosome 3.CD2 interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. With the use of transgenic mice, such an LCR was identified within the 3-prime flanking region of the human CD2 gene.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
FC00570-Biotin is guaranteed for Flow Cytometry Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
User needs to optimize the dilution ratio for this antibody.
Validation Images & Assay Conditions
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Lymphocytes gated PBMCs stained with anti-human CD2 Biotin (clone OKT 11) (red histogram) followed by a secondary staining with SA-PE. PBMCs stained with isotype IgG1 biotin followed by a secondary staining with SA-PE (Blue histogram) was used as control.
Protein Target Info & Infographic
Gene/Protein Information For CD2 (Source: Uniprot.org, NCBI)
Gene Name
CD2
Full Name
T-cell surface antigen CD2
Weight
39448 MW
Alternative Names
T-cell surface antigen CD2;Erythrocyte receptor;LFA-2;LFA-3 receptor;Rosette receptor;T-cell surface antigen T11/Leu-5;CD2;CD2;SRBC; CD2 LFA-2, SRBC, T11 CD2 molecule T-cell surface CD2|CD2 (p50), sheep red blood cell receptor|LFA-3 receptor|T-cell surface T11/Leu-5|erythrocyte receptor|lymphocyte-function -2|rosette receptor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CD2, check out the CD2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CD2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-human CD2 Monoclonal Antibody Biotin Conjugated, Flow Validated (FC00570-Biotin)
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