Anti-Human CASR DyLight® 488 conjugated Antibody(monoclonal, 11E9)

Product Name

Anti-Human CASR DyLight® 488 conjugated Antibody(monoclonal, 11E9)

View all Calcium-sensing R/CaSR Antibodies

SKU/Catalog Number

M00574-Dyl488

Size

100 μg/vial

Form

Liquid

Description

Boster Bio Anti-Human CASR DyLight® 488 conjugated Antibody (monoclonal, 11E9) catalog # M00574-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Storage & Handling

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Cite This Product

Anti-Human CASR DyLight® 488 conjugated Antibody(monoclonal, 11E9) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00574-Dyl488)

Host

Mouse

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Clonality

Monoclonal

Clone Number

Clone: 11E9

Isotype

Mouse IgG2b

Immunogen

E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

M00574-Dyl488 is reactive to CASR in Human

Reconstitution

Observed Molecular Weight

39 kDa

Calculated molecular weight

120.675kDa

Background of Calcium-sensing R/CaSR

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M00574-Dyl488 is guaranteed for Flow Cytometry Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells

Validation Images & Assay Conditions

Gene/Protein Information For CASR (Source: Uniprot.org, NCBI)

Alternative Names

Extracellular calcium-sensing receptor; CaR CASR CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasR calcium sensing receptor extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1|parathyroid cell calcium-sensing receptor 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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