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Zinc finger protein GLI1 Antibodies
AND GLI1 ELISA kits, Zinc finger protein GLI1 Proteins
Many biological assays use antibodies to detect Zinc finger protein GLI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein GLI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein GLI1 antibodies...
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GLI1 Infographic by Boster Bio
All GLI1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$405
Cat # A00527-1
100ul
Cat # A00527-1
100ul
Human, Mouse, Rat
IHC, WB
$523
Cat # M00527-1
100 µl
Cat # M00527-1
100 µl
GLI1 Overview
Facts about Zinc finger protein GLI1.
Zinc finger protein GLI1 (GLI1)
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340).
Binds to the DNA consensus sequence 5'- GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340).May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract.
Gene Information
| Human | |
|---|---|
| Gene Name: | GLI1 |
| Uniprot: | P08151 |
| Entrez: | 2735 |
Family
| Belongs to: |
|---|
| GLI C2H2-type zinc-finger protein family |
Alternative Names
GLI family zinc finger 1; GLI1; GLI-1; glioma-associated oncogene family zinc finger 1; glioma-associated oncogene homolog 1 (zinc finger protein); Glioma-associated oncogene; GLIzinc finger protein GLI1; Oncogene GLI
Molecular Weight
Mass (kDA):
117.904 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.3 |
| Sequence: | 12; NC_000012.12 (57459785..57472451) |
Tissue Specificity
Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761).
Subcellular Localizations
Cytoplasm. Nucleus. Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441).; [Isoform 2]: Cytoplasm. Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Medulloblastoma
- Basal Cell Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Malignant Neoplasm Of Pancreas
- Adenocarcinoma
- Brain Neoplasms
- Carcinogenesis
Interacting Proteins
- CRYBA4
- GCC1
- ITCH
- PRKAA2
- PRKCI
- RPS6KB1
- STK36
- SUFU
- TRIM42
- Zic1
Pathways
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Cycle
- Localization
- Angiogenesis
- Cell Differentiation
- Tissue Homeostasis
- Methylation
- Cell Death
- Neurogenesis
- Rna Interference
- Regeneration
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Ubiquitination
- Deacetylation
Research Areas
- Cancer
- Signal Transduction
- Stem Cell Signaling Pathway
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLI1
bosterbio.com/bosterbio-gene-info-cards/GLI1
References
PMID: 2832761 by Kinzler K.W., et al. The GLI gene is a member of the Kruppel family of zinc finger proteins.
PMID: 19706761 by Lo H.W., et al. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
1 Publications of Boster Zinc finger protein GLI1 Antibodies & ELISA Kits
- PubMed ID: 24553082, Duan F, Lin M, Li C, Ding X, Qian G, Zhang H, Ge S, Fan X, Li J. Cancer Biol The...
*More publications can be found for each product on its corresponding product page