Anti-Cyclin O CCNO Antibody

Product Name

Anti-Cyclin O CCNO Antibody

View all Cyclin-O Antibodies

SKU/Catalog Number

A05899

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Cyclin O CCNO Antibody (Catalog # A05899). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Cyclin O antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Cyclin O CCNO Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05899)

Host

Rabbit

Contents

Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Cyclin O antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Cyclin O. The immunogen is located within the first 50 amino acids of Cyclin O.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms.

Reactive Species

A05899 is reactive to CCNO in Human, Mouse, Rat

Applications

A05899 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

38096 MW

Background of Cyclin-O

Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Click image to see more details

Western blot analysis of Cyclin O in mouse bladder tissue lysate with Cyclin O antibody at (A) 1 and (B) 2 μg/mL.

Gene/Protein Information For CCNO (Source: Uniprot.org, NCBI)

Alternative Names

CCNO cyclin O; CCNU; UDG2 CCNO CCNU, CILD29, UDG2 cyclin O cyclin-O|cyclin U|cyclin domain containing

For more info on CCNO, check out the CCNO Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CCNO: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Take me to the CCNO Infographic

Here are featured tools and databases that you might find useful.

• Boster's Pathways Library
• Protein Databases
• Bioscience Research Protocol Resources
• Data Processing & Analysis Software
• Photo Editing Software
• Scientific Literature Resources
• Research Paper Management Tools
• Molecular Biology Software
• Primer Design Tools
• Bioinformatics Tools
• Phylogenetic Tree Analysis