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Cyclin-dependent kinase 4 Antibodies
AND CDK4 ELISA kits, Cyclin-dependent kinase 4 Proteins
Many biological assays use antibodies to detect Cyclin-dependent kinase 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-dependent kinase 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-dependent kinase 4 antibodies...
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CDK4 Infographic by Boster Bio
All CDK4 Products
Product
Figures
Specificity
Applications
Price
Anti-Cdk4 Antibody Picoband®
19 Citations 5 Q&As
Human, Mouse, Rat
IF, IHC, WB
$370
Cat # PB9535
100 μg/vial
Cat # PB9535
100 μg/vial
Anti-CDK4 Antibody (Monoclonal, DCS-31)
12 Citations 15 Q&As
Human, Mouse, Rat
ICC, WB
$370
Cat # MA1020
100 μg/vial
Cat # MA1020
100 μg/vial
Anti-Cyclin-dependent kinase 4 Cdk4 Antibody Picoband®
11 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # PA1428-1
100 μg/vial
Cat # PA1428-1
100 μg/vial
Anti-CDK4 Rabbit Monoclonal Antibody
2 Citations 16 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00159-1
100 μl
Cat # M00159-1
100 μl
Anti-CDK4 Rabbit Monoclonal Antibody
3 Citations 16 Q&As
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # M00159
100 μl
Cat # M00159
100 μl
Anti-Cyclin-dependent kinase 4 Cdk4 Antibody
1 Citations
Human, Mouse, Rat
IP, IF, ICC, WB
$405
Cat # A00159
100ul
Cat # A00159
100ul
Human
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A00159-1
100ul
Cat # A00159-1
100ul
CDK4 Overview
Facts about Cyclin-dependent kinase 4.
Cyclin-dependent kinase 4 (CDK4)
Ser/Thr-kinase part of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are important integrators of various mitogenenic and antimitogenic signals.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDK4 |
| Uniprot: | P11802 |
| Entrez: | 1019 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CDK4; Cell division protein kinase 4; CMM3; cyclin-dependent kinase 4; EC 2.7.11; EC 2.7.11.22; melanoma cutaneous malignant, 3; MGC14458; PSK-J3; PSK-J3cell division kinase 4
Molecular Weight
Mass (kDA):
33.73 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q14.1 |
| Sequence: | 12; NC_000012.12 (57747727..57752310, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Melanoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Growth Arrest
- Skin Neoplasms
- Leukemia
Interacting Proteins
- CCND1
- CCND2
- CCND3
- CDC37
- CDK7
- CDKN1A
- CDKN1B
- CDKN2A
- CDKN2B
- CDKN2C
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Cycle Arrest
- G1 Phase
- Cell Growth
- S Phase
- Cell Death
- Pathogenesis
- Localization
- Senescence
- Cell Division
- Induction Of Apoptosis
- Hyperphosphorylation
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Dephosphorylation
- Acetylation
- Ubiquitination
- Reduction
- Demethylation
- Oxidation
- Biotinylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Core ESC-Like Genes
- mTOR Pathway
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDK4
bosterbio.com/bosterbio-gene-info-cards/CDK4
References
PMID: 9192850 by Elkahloun A.G., et al. Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.
PMID: 7652577 by Wolfel T., et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.
20 Publications of Boster Cyclin-dependent kinase 4 Antibodies & ELISA Kits
- PubMed ID: 10.7150/ijms.3859, Effect of Bone Morphogenetic Protein-2 on Proliferation and Apoptosis of Gastric...
- PubMed ID: 10.3892/or.2016.4935, Platycodin D, a metabolite of Platycodin grandiflorum, inhibits highly metastati...
- PubMed ID: 10.3389/fonc.2021.648985, Combined Anti-Cancer Effects of Platycodin D and Sorafenib on Androgen-Independe...
- PubMed ID: 10.1016/j.neulet.2009.09.052, Dynamic changes of cell cycle elements in the ischemic brain after bone marrow s...
- PubMed ID: 10.1016/j.mce.2020.111005, Glucagon-like peptide 1 treatment reverses vascular remodelling by downregulatin...
- PubMed ID: 10.1002/cbin.10892, OAMDP, a novel podophyllotoxin derivative, induces apoptosis, cell cycle arrest ...
- PubMed ID: -, Lu Kong,Yongya Wu,Wangcheng Hu,Lin Liu,Yuying Xue,Geyu Liang,Mechanisms underlyi...
- PubMed ID: 22359486, Effect of Bone Morphogenetic Protein-2 on Proliferation and Apoptosis of Gastric...
- PubMed ID: 29048616, Liao S, Xiao S, Chen H, Zhang M, Chen Z, Long Y, Gao L, He J, Ge Y, Yi W, Wu M, ...
- PubMed ID: 24076388, Deng L, Lu Y, Zhao X, Sun Y, Shi Y, Fan H, Liu C, Zhou J, Nie Y, Wu K, Fan D, Gu...
- PubMed ID: 21491996, Liu W, Dai Q, Lu N, Wei L, Ha J, Rong J, Mu R, You Q, Li Z, Guo Q. Biochem Cell ...
- PubMed ID: 24105880, Wang Hy, Huang Rp, Han P, Xue Db, Li Hb, Liu B, Shan P, Wang Qs, Li Ks, Li Hl. C...
- PubMed ID: 22108090, Li Bh, Xu Sb, Li F, Zou Xg, Saimaiti A, Simayi D, Wang Yh, Zhang Y, Yuan J, Zhan...
- PubMed ID: 24788349, Zhang H, Zhao B, Huang C, Meng Xm, Bian Eb, Li J. Plos One. 2014 May 2;9(5):E955...
- PubMed ID: 20025889, Han W, Liu Gn. Life Sci. 2010 Feb 13;86(7-8):234-43. Doi: 10.1016/J.Lfs.2009.12....
- PubMed ID: 25734831, Ren J, Huang Q, Xu Y, Yang M, Yang J, Hu K. Anticancer Drugs. 2015 Jul;26(6):599...
- PubMed ID: 25431082, Zhou R, Lu Z, Liu K, Guo J, Liu J, Zhou Y, Yang J, Mi M, Xu H. Curr Cancer Drug ...
- PubMed ID: 22705907, Cai K, Xu J, Zhang Y. Neurosci Lett. 2012 Jul 26;522(1):62-6. Doi: 10.1016/J.Neu...
- PubMed ID: 24084445, Li B, Xu Yj, Chu Xm, Gao Mh, Wang Xh, Nie Sm, Yang F, Lv Cy. Immunol Lett. 2013 ...
- PubMed ID: 18686097, Li J, Bao Y, Lam W, Li W, Lu F, Zhu X, Liu J, Wang H. Immunopharmacol Immunotoxi...
*More publications can be found for each product on its corresponding product page