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Product Info Summary
| SKU: | A06612 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-Borealin CDCA8 Antibody
SKU/Catalog Number
A06612
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Borealin CDCA8 Antibody (Catalog # A06612). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CDCA8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Borealin CDCA8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06612)
Host
Rabbit
Contents
CDCA8 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CDCA8 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8. The immunogen is located within the first 50 amino acids of CDCA8.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family.
Reactive Species
A06612 is reactive to CDCA8 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
31323 MW
Background of Borealin
CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06612 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CDCA8 antibody can be used for detection of CDCA8 by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CDCA8 in Rat kidney lysate with CDCA8 antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of CDCA8 in rat kidney tissue with CDCA8 antibody at 20 μg/mL.
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Immunofluorescence of CDCA8 in Rat Kidney cells with CDCA8 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CDCA8 (Source: Uniprot.org, NCBI)
Gene Name
CDCA8
Full Name
Borealin
Weight
31323 MW
Superfamily
borealin family
Alternative Names
BOR, DasraB, MESRGP, BOREALIN, PESCRG3, Borealin, Cell division cycle-associated protein 8, hDasra-B Cdca8|4831429J16Rik, AU044747, BOR, Bo, Borealin, D4Ertd421, D4Ertd421e, Da, DasraB, MESRGP|cell division cycle associated 8|borealin|MESrg|cell division cycle-associated protein 8|embryonic stem cell-related
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CDCA8, check out the CDCA8 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CDCA8: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Borealin CDCA8 Antibody (A06612)
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