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Product Info Summary
| SKU: | A07197 |
|---|---|
| Size: | 80 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-BBS5 Antibody (Center)
SKU/Catalog Number
A07197
Size
80 µl
Description
Boster Bio Anti-BBS5 Antibody (Center) (Catalog # A07197). Tested in WB application(s). This antibody reacts with Human.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-BBS5 Antibody (Center) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07197)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This BBS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A07197 is reactive to Bbs5 in Human
Applications
A07197 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
38755 Da
Background of Bbs5
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
Validation Images & Assay Conditions
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Western blot analysis of lysate from K562 cell line, using BBS5 Antibody (Center). A07197 was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
Protein Target Info & Infographic
Gene/Protein Information For Bbs5 (Source: Uniprot.org, NCBI)
Gene Name
Bbs5
Full Name
Bardet-Biedl syndrome 5 protein homolog
Weight
38755 Da
Superfamily
BBS5 family
Alternative Names
Bardet-Biedl syndrome 5 protein; Bardet-Biedl syndrome 5; DKFZp762I194 Bbs5|1700049I01Rik, 2700023J09Rik|Bardet-Biedl syndrome 5 (human)|Bardet-Biedl syndrome 5 protein homolog|novel DUF1448 protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Bbs5, check out the Bbs5 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Bbs5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-BBS5 Antibody (Center) (A07197)
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