Beta-secretase 2 Antibodies

AND BACE2 ELISA kits, Beta-secretase 2 Proteins

Many biological assays use antibodies to detect Beta-secretase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-secretase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-secretase 2 antibodies...

We validate the specificity of these antibodies to Beta-secretase 2 by testing them on tissues known to express BACE2 positively and negatively. Browse below to find the BACE2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: TMEM184B

BACE2 Infographic by Boster Bio

All BACE2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

BACE2 (NM_012105) Human Over-expression Lysate

Human

$628
Cat # LS025825
100 µg

BACE2 Overview

Facts about Beta-secretase 2.

BACE2 3D structure. Source: alphafold

Beta-secretase 2 (BACE2)

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, involving residues 690 and 691, causing the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment that's later released by gamma-secretase.

Additionally, it has been shown that it may cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).

Gene Information

Human
Gene Name:	BACE2
Uniprot:	Q9Y5Z0
Entrez:	25825

Family

Belongs to:

peptidase A1 family

Alternative Names

AEPLC; Asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; BACE2; BACE-2; beta secretase 2; beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAPBAE2; EC 3.4.23; EC 3.4.23.45; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic

Molecular Weight

Mass (kDA):
56.18 kDA

Genomic Context


Human

Location:	21q22.2-q22.3
Sequence:	21; NC_000021.9 (41168160..41282530)

Tissue Specificity

Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.