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Arc Antibodies
AND Arc ELISA kits, Arc Proteins
Many biological assays use antibodies to detect Arc, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Arc in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Arc antibodies...
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Arc Infographic by Boster Bio
All Arc Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1607
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1607
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
WB
$523
Cat # M08455
100 µl
Cat # M08455
100 µl
Arc Overview
Facts about Activity-regulated cytoskeleton-associated protein.
Activity-regulated cytoskeleton-associated protein (Arc)
Master regulator of synaptic plasticity that self- assembles to virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (By similarity). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, in which ARC mRNA can undergo activity-dependent translation (By similarity).
ARC capsids are endocytosed and have the ability to transfer ARC mRNA to the cytoplasm of neurons (By similarity). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the creation of long-term memory (PubMed:29264923, PubMed:24094104).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Arc |
| Uniprot: | Q9WV31 |
| Entrez: | 11838 |
Family
| Belongs to: |
|---|
| ARC/ARG3.1 family |
Alternative Names
activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; KIAA0278Arg3.1Activity-regulated gene 3.1 protein homolog
Molecular Weight
Mass (kDA):
45.321 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15 D3|15 34.25 cM |
| Sequence: | 15; |
Tissue Specificity
Expressed in brain and testis (PubMed:12493697). In primary visual cortex, detected in all cortical layers with the exception of layer 5: present at highest level in layers 2/3 and 4, the predominant sites of ocular dominance plasticity (at protein level) (PubMed:20228806). Also expressed in skin-migratory dendritic cells (PubMed:28783680).
Diseases
- Acquired Immunodeficiency Syndrome
- Aids Related Complex
- Hiv Infections
- Pain
- Neoplasms
- Flexed Fetal Attitude
- Malignant Neoplasms
- Fracture
- Immunologic Deficiency Syndromes
- Nervousness
- Infective Disorder
- Obesity
Pathways
- Reflex
- Secretion
- Localization
- Transport
- Translation
- Aging
- Pathogenesis
- Energy Homeostasis
- Feeding Behavior
- Innervation
- Transposition
- Cell Death
- Ossification
PTMs
- Phosphorylation
- Cleavage
- Oxidation
- Nitration
- Dephosphorylation
- Reduction
- Acetylation
- Biotinylation
- Methylation
- Carboxylation
Research Areas
- Apoptosis
- Neuroscience
- Sensory Systems
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Arc
bosterbio.com/bosterbio-gene-info-cards/Arc
References
PMID: 11466419 by Waltereit R., et al. Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation.
PMID: 10727859 by Liu D., et al. Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis.