ABHD2 Antibodies

AND ABHD2 ELISA kits, ABHD2 Proteins

Many biological assays use antibodies to detect ABHD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABHD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABHD2 antibodies...

We validate the specificity of these antibodies to ABHD2 by testing them on tissues known to express ABHD2 positively and negatively. Browse below to find the ABHD2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABHD2 Infographic by Boster Bio

All ABHD2 Products

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Product

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Specificity

Applications

Price

Anti-Monoacylglycerol lipase ABHD2 ABHD2 Antibody

3 Q&As

Human, Mouse

ELISA, IF, WB

$399
Cat # A11055
100μl

ABHD2 (NM_007011) Human Over-expression Lysate

Human

$628
Cat # LS011057
100 µg

ABHD2 Overview

Facts about Monoacylglycerol lipase ABHD2.

ABHD2 3D structure. Source: alphafold

Monoacylglycerol lipase ABHD2 (ABHD2)

Progesterone-dependent acylglycerol lipase which catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) into glycerol and arachidonic acid (AA) (PubMed:26989199).

Plays a crucial role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, resulting in calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).

Gene Information

Human
Gene Name:	ABHD2
Uniprot:	P08910
Entrez:	11057

Family

Belongs to:

AB hydrolase superfamily

Alternative Names

abhydrolase domain containing 2; abhydrolase domain-containing protein 2; alpha/beta hydrolase domain containing protein 2; EC 3.1.1; EC 3.1.1.-; HS1-2; LABH2PHPS1-2; Lung alpha/beta hydrolase 2; MGC111112; MGC26249; Protein PHPS1-2

Molecular Weight

Mass (kDA):
48.315 kDA

Genomic Context


Human

Location:	15q26.1
Sequence:	15; NC_000015.10 (89088422..89202355)

Tissue Specificity

Present in sperm (at protein level).

Subcellular Localizations

Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.

Diseases

Hepatitis B
Malignant Neoplasms
Neoplasms
Pulmonary Emphysema
Hepatitis
Virus Diseases
Hyperplasia
Retinal Dystrophies
Neoplasm Metastasis
Night Blindness
Retinal Degeneration
Tumor Progression

Glioma
Malignant Tumor Of Colon
Coronary Artery Disease
Carcinoma
Dental Plaque
Chronic Stable Angina
Colorectal Cancer

Pathways

Cell Migration
Muscle Cell Migration
Smooth Muscle Cell Migration
Pathogenesis
Viral Replication

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABHD2

References

PMID: 2843827 by Rapiejko P.J., et al. Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family.

PMID: 27247428 by M N.K., et al. Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase.