Integrin alpha-IIb Antibodies

AND ITGA2B ELISA kits, Integrin alpha-IIb Proteins

Many biological assays use antibodies to detect Integrin alpha-IIb, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-IIb in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-IIb antibodies...

We validate the specificity of these antibodies to Integrin alpha-IIb by testing them on tissues known to express ITGA2B positively and negatively. Browse below to find the ITGA2B antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ITGA2B Infographic by Boster Bio

All ITGA2B Products

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Specificity

Applications

Price

Anti-CD41/Integrin alpha 2b/ITGA2B Antibody Picoband®

3 Citations 2 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9647
100 μg/vial

Anti-CD41 ITGA2B Rabbit Monoclonal Antibody

1 Citations 4 Q&As

Human

IHC, WB

$370
Cat # M01102
100 μl

Anti-Human ITGA2B DyLight® 488 conjugated Antibody

1 Citations

Human

Flow Cytometry

$515
Cat # A01102-Dyl488
100 μg/vial

Anti-Human ITGA2B DyLight® 550 conjugated Antibody

1 Citations

Human

Flow Cytometry

$515
Cat # A01102-Dyl550
100 μg/vial

Anti-Zebrafish itga2b/GPIIb Antibody

Zebrafish

$470
Cat # DZ01102
200 μl/vial

Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody

Human, Primate

Flow Cytometry, IHC-F

$301
Cat # M01102-1
0.1 mg

Anti-CD41/Integrin Alpha 2B/ITGA2B Antibody Picoband®

Human

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A01102-1
100 µg/vial

ITGA2B Overview

Facts about Integrin alpha-IIb.

ITGA2B 3D structure. Source: alphafold

Integrin alpha-IIb (ITGA2B)

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide variety of ligands.

It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen.

Gene Information

Human
Gene Name:	ITGA2B
Uniprot:	P08514
Entrez:	3674

Family

Belongs to:

integrin alpha chain family

Alternative Names

CD41 antigen; CD41; CD41BHPA3; GP2B; GP2Bintegrin alpha-IIb; GPalpha IIb; GPIIb; GTA; HPA3; Integrin alpha 2b; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41); integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B); ITGA2b; ITGAB; platelet fibrinogen receptor, alpha subunit; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK

Molecular Weight

Mass (kDA):
113.377 kDA

Genomic Context


Human

Location:	17q21.31
Sequence:	17; NC_000017.11 (44372181..44389649, complement)

Tissue Specificity

Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974).

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Thrombasthenia
Hemorrhage
Tissue Adhesions
Von Willebrand Disease
Thrombosis
Bleeding Tendency
Thrombus
Myocardial Infarction
Infarction
5,10-methylenetetrahydrofolate Reductase Deficiency
Hereditary Diseases
Inflammation

Cerebrovascular Accident
Disease Of Adrenal Medulla
Immunologic Deficiency Syndromes
Angina, Unstable
Hemorrhagic Disorders
Bernard-soulier Syndrome
Cardiovascular Diseases

Interacting Proteins

FLNA
ITGB3

Pathways

Platelet Aggregation
Platelet Activation
Hemostasis
Secretion
Pathogenesis
Mrna Splicing
Reverse Transcription
Localization
Coagulation
Protein Phosphorylation
Transport
Clathrin-mediated Endocytosis
Developmental Process

Immune Response
Inner Ear Development
Embryo Development
Blastocyst Formation
Membrane Depolarization
Cell Cycle
Cyclooxygenase Pathway

PTMs

Phosphorylation
Sulphation
Glycosylation

Acetylation
Dephosphorylation
Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA2B

References

PMID: 2439501 by Poncz M., et al. Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

PMID: 2345548 by Frachet P., et al. GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs.

3 Publications of Boster Integrin alpha-IIb Antibodies & ELISA Kits

PubMed ID: 10.1038/s41598-017-12073-4, Thrombopoietic stimulating activity of rhTyrRS (Y341A)
PubMed ID: -, Leila Revollo,Glenn Merrill-Skoloff,Karen De Ceunynck,James Dilks,Mattia Bordoli...
PubMed ID: 28939876, Thrombopoietic stimulating activity of rhTyrRS (Y341A)

*More publications can be found for each product on its corresponding product page