Zinc finger-containing ubiquitin peptidase 1 (Zup1)

Deubiquitinase with endodeubiquitinase action that specifically interacts with and cleaves'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains.

Plays an essential role in genome stability pathways, working to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.