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- Table of Contents
Facts about E3 ubiquitin-protein ligase ZNRF3.
Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. .
Human | |
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Gene Name: | ZNRF3 |
Uniprot: | Q9ULT6 |
Entrez: | 84133 |
Belongs to: |
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ZNRF3 family |
E3 ubiquitin-protein ligase ZNRF3
Mass (kDA):
100.574 kDA
Human | |
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Location: | 22q12.1 |
Sequence: | 22; NC_000022.11 (28800657..29057488) |
Cell membrane; Single-pass type I membrane protein.
PMID: 22575959 by Hao H.X., et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
PMID: 29769720 by Szenker-Ravi E., et al. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.