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- Table of Contents
Facts about GATOR complex protein WDR24.
It's negatively regulated by the upstream amino acid detectors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of this TORC1 complicated, promotes the acidification of lysosomes and eases autophagic flux (PubMed:27166823).
Human | |
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Gene Name: | WDR24 |
Uniprot: | Q96S15 |
Entrez: | 84219 |
Belongs to: |
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WD repeat WDR24 family |
GATOR complex protein WDR24
Mass (kDA):
88.207 kDA
Human | |
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Location: | 16p13.3 |
Sequence: | 16; NC_000016.10 (684622..690661, complement) |
Lysosome membrane.
PMID: 25263562 by Chantranupong L., et al. The Sestrins interact with GATOR2 to negatively regulate the amino- acid-sensing pathway upstream of mTORC1.
PMID: 25457612 by Parmigiani A., et al. Sestrins inhibit mTORC1 kinase activation through the GATOR complex.