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- Table of Contents
Facts about (E3-independent) E2 ubiquitin-conjugating enzyme.
Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at several sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1.
Human | |
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Gene Name: | UBE2O |
Uniprot: | Q9C0C9 |
Entrez: | 63893 |
Belongs to: |
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ubiquitin-conjugating enzyme family |
E2-230K; EC 6.3.2.19; FLJ12878; KIAA1734; Ubiquitin carrier protein O; ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; ubiquitin-conjugating enzyme E2O; Ubiquitin-protein ligase O
Mass (kDA):
141.293 kDA
Human | |
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Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (76389456..76453234, complement) |
Predominantly expressed in skeletal muscle and heart.
Cytoplasm. Nucleus. Mainly localizes to the cytoplasm.
PMID: 11311559 by Yokota T., et al. Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k.
PMID: 23452853 by Hao Y.H., et al. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.