TYROBP Antibodies

AND TYROBP ELISA kits, TYROBP Proteins

Many biological assays use antibodies to detect TYROBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TYROBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TYROBP antibodies...

We validate the specificity of these antibodies to TYROBP by testing them on tissues known to express TYROBP positively and negatively. Browse below to find the TYROBP antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TYROBP Infographic by Boster Bio

All TYROBP Products

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Product

Figures

Specificity

Applications

Price

Anti-DAP12 TYROBP Antibody

Human

Flow Cytometry, IHC, WB

$405
Cat # A01996
100ul

Anti-DAP12 Rabbit Monoclonal Antibody

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M01996-1
100 μl/vial

DAP12 (TYROBP) (NM_003332) Human Over-expression Lysate

Human

$628
Cat # LS007305
100 µg

TYROBP Overview

Facts about TYRO protein tyrosine kinase-binding protein.

TYROBP 3D structure. Source: alphafold

TYRO protein tyrosine kinase-binding protein (TYROBP)

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes leads to cellular activation.

Involved for instance in neutrophil activation mediated by integrin. .

Gene Information

Human
Gene Name:	TYROBP
Uniprot:	O43914
Entrez:	7305

Family

Belongs to:

TYROBP family

Alternative Names

DAP12; DAP12PLOSL; DNAX-activation protein 12; KARAP; KARAPPLO-SL; KAR-associated protein; killer activating receptor associated protein; Killer-activating receptor-associated protein; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein; TYROBP

Molecular Weight

Mass (kDA):
12.179 kDA

Genomic Context


Human

Location:	19q13.12
Sequence:	19; NC_000019.10 (35904403..35908295, complement)

Tissue Specificity

Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Dementia
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Inflammation
Bone Cysts
Neoplasms
Leukoencephalopathies
Presenile Dementia
Arthritis
Rheumatoid Arthritis
Infective Disorder
Cytomegalovirus Infections
Autoimmune Reaction

Nervousness
Virus Diseases
Tissue Adhesions
Hereditary Diseases
Albers-schonberg Disease
Osteochondrodysplasias
Inflammatory Response

Interacting Proteins

KIR2DS5
NCR2
SIRPB1
TREM2

Pathways

Cell Activation
Secretion
Cytokine Production
Pathogenesis
Bone Resorption
Immune Response
Osteoclast Differentiation
Osteoclast Development
Inflammatory Response
Cell Proliferation
Bone Remodeling
Phagocytosis
Cytolysis

Rna Interference
Cytokine Secretion
T Cell Proliferation
Cell Development
T Cell Activation
Myelination
Macrophage Activation

PTMs

Phosphorylation
Biotinylation

Cleavage
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TYROBP

References

PMID: 9490415 by Lanier L.L., et al. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.

PMID: 16344560 by Kimura K., et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.