TRPA1 Antibodies

AND TRPA1 ELISA kits, TRPA1 Proteins

Many biological assays use antibodies to detect TRPA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPA1 antibodies...

We validate the specificity of these antibodies to TRPA1 by testing them on tissues known to express TRPA1 positively and negatively. Browse below to find the TRPA1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRPA1 Infographic by Boster Bio

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Anti-TRPA1/TSA Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A00453-2
100 μg/vial

TRPA1 Overview

Facts about Transient receptor potential cation channel subfamily A member 1.

TRPA1 3D structure. Source: alphafold

Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Receptor-activated non-selective cation channel involved in detection of pain and maybe also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central part in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as olive oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126).

Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312).

Gene Information

Human
Gene Name:	TRPA1
Uniprot:	O75762
Entrez:	8989

Family

Belongs to:

transient receptor (TC 1.A.4) family

Alternative Names

ANKTM1ankyrin-like with transmembrane domains 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel, subfamily A, member 1

Molecular Weight

Mass (kDA):
127.501 kDA

Genomic Context


Human

Location:	8q21.11
Sequence:	8; NC_000008.11 (72021250..72094885, complement)

Tissue Specificity

Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Pain
Inflammation
Hyperalgesia
Nervousness
Neuralgia
Neurogenic Inflammation
Coughing
Hyperalgesias, Mechanical
Asthma
Nerve Damage
Chronic Pain

Cold Intolerance
Pathological Dilatation
Malignant Neoplasms
Tissue Damage
Edema
Colitis

Pathways

Hypersensitivity
Sensitization
Reflex
Secretion
Pathogenesis
Synaptic Transmission
Localization
Innervation
Transport
Inflammatory Response
Vasodilation
Thermotaxis
Phototransduction

Sensory Perception
Membrane Depolarization
Insulin Secretion
Micturition
Immune Response
Mucus Secretion
Ion Transport

PTMs

Phosphorylation
Oxidation
Cleavage
Biotinylation
Nitrosylation

Reduction
Hydroxylation
Farnesylation
Acetylation
Dephosphorylation

Research Areas

Neuronal Cell Markers
Neuroscience
Neurotransmission
Sensory Systems

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPA1

References

PMID: 10066796 by Jaquemar D., et al. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts.

PMID: 25389312 by Moparthi L., et al. Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.