TRIM37 Antibodies

AND TRIM37 ELISA kits, TRIM37 Proteins

Many biological assays use antibodies to detect TRIM37, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM37 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM37 antibodies...

We validate the specificity of these antibodies to TRIM37 by testing them on tissues known to express TRIM37 positively and negatively. Browse below to find the TRIM37 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRIM37 Infographic by Boster Bio

All TRIM37 Products

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Specificity

Applications

Price

TRIM37 (NM_015294) Human Over-expression Lysate

Human

$628
Cat # LS004591
100 µg

TRIM37 Overview

Facts about E3 ubiquitin-protein ligase TRIM37.

TRIM37 3D structure. Source: alphafold

E3 ubiquitin-protein ligase TRIM37 (TRIM37)

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972).

Mediates monoubiquitination of'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: partners with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV action (PubMed:24317724).

Gene Information

Human
Gene Name:	TRIM37
Uniprot:	O94972
Entrez:	4591

Family

Belongs to:

TRIM/RBCC family

Alternative Names

EC 6.3.2.-; KIAA0898Tripartite motif-containing protein 37; Mulibrey nanism protein; MULRING-B-box-coiled-coil protein; POB1E3 ubiquitin-protein ligase TRIM37; TEF3; tripartite motif containing 37; tripartite motif-containing 37

Molecular Weight

Mass (kDA):
107.906 kDA

Genomic Context


Human

Location:	17q22
Sequence:	17; NC_000017.11 (58968010..59106880, complement)

Tissue Specificity

Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).

Subcellular Localizations

Cytoplasm, perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.

Diseases

Dwarfism
Mulibrey Nanism
Neoplasms
Hepatomegaly
Heart Diseases
Growth Disorders
Malignant Neoplasms
Nephroblastoma
Stenosis
Peroxisomal Disorders
Kidney Neoplasm
Ovarian Neoplasm

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Insulin Resistance
Cell Transformation, Neoplastic
Growth Retardation
Leukemia

Interacting Proteins

AXIN1
BYSL
CDC20B
COPB1
CWF19L2

DDX6
FAM161A
FAM50B
KAT5
MCRS1

PNKP
PRC1
RASD1
RPL9
SCNM1

SSX2IP
UBASH3A
ZMAT2
ZNF329
ZNF417

Pathways

Localization
Pathogenesis
Methylation
Cell Adhesion
Organ Development
Translation

Oncogenesis

PTMs

Methylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIM37

References

PMID: 10888877 by Avela K., et al. Gene encoding a new RING-B-box-coiled-coil protein is mutated in mulibrey nanism.

PMID: 11938494 by Kallijarvi J., et al. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder.