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- Table of Contents
Facts about T cell receptor alpha constant.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
Human | |
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Gene Name: | TRAC |
Uniprot: | P01848 |
Entrez: | 28755 |
Belongs to: |
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No superfamily |
T cell receptor alpha constant
Mass (kDA):
15.717 kDA
Human | |
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Location: | 14q11.2 |
Sequence: | 14; NC_000014.9 (22547506..22552132) |
Cell membrane.
PMID: 3875483 by Rabbitts T.H., et al. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.
PMID: 3873654 by Yanagi Y., et al. Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.