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Tonsoku-like protein Antibodies
AND TONSL ELISA kits, Tonsoku-like protein Proteins
Many biological assays use antibodies to detect Tonsoku-like protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tonsoku-like protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tonsoku-like protein antibodies...
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TONSL Infographic by Boster Bio
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TONSL Overview
Facts about Tonsoku-like protein.
Tonsoku-like protein (TONSL)
Part of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks.
It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
Gene Information
| Human | |
|---|---|
| Gene Name: | TONSL |
| Uniprot: | Q96HA7 |
| Entrez: | 4796 |
Family
| Belongs to: |
|---|
| Tonsoku family |
Alternative Names
IkappaBR; I-kappa-B-related protein; IKBRFLJ40087; Inhibitor of kappa B-related protein; NF-kappa-B inhibitor-like protein 2; NFKBIL2tonsoku-like protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cellsinhibitor-like 2ikappaBR; tonsoku-like, DNA repair protein
Molecular Weight
Mass (kDA):
150.929 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.3 |
| Sequence: | 8; NC_000008.11 (144428775..144444488, complement) |
Tissue Specificity
Expressed in heart, skeletal muscle and tracheal epithelial cells.
Subcellular Localizations
Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
Diseases
- Genomic Instability
- Physiological Stress
- Inflammation
- Acquired Immunodeficiency Syndrome
- Ischemia
- Emotional Distress
- Inflammatory Bowel Diseases
- Inflammatory Response
- Pneumococcal Infections
- Pneumonia
- Immunologic Deficiency Syndromes
- Systemic Infection
- Hemorrhage
Interacting Proteins
- MMS22L
Pathways
- Dna Replication
- Proteolysis
- Cell Death
- Nuclear Migration
- Dna Damage Checkpoint
- S Phase
- Immune Response
- Hypersensitivity
- Pathogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TONSL
bosterbio.com/bosterbio-gene-info-cards/TONSL
References
PMID: 7738005 by Ray P., et al. Cloning of a differentially expressed I kappa B-related protein.
PMID: 11246458 by Norman D.A., et al. Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2).