This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
TNFRSF10B Antibodies
AND TNFRSF10B ELISA kits, TNFRSF10B Proteins
Many biological assays use antibodies to detect TNFRSF10B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNFRSF10B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNFRSF10B antibodies...
Previous: CBLIF
Next: DYRK4
TNFRSF10B Infographic by Boster Bio
All TNFRSF10B Products
Product
Figures
Specificity
Applications
Price
Anti-DR5/TNFRSF10B Antibody Picoband®
2 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A00410
100 μg/vial
Cat # A00410
100 μg/vial
SDS-PAGE, Bioactivity
$250
Cat # PROTO14763
Starting from 10ug
Cat # PROTO14763
Starting from 10ug
Human, Monkey, Mouse
IHC, WB
$523
Cat # M00410-1
100 µl
Cat # M00410-1
100 µl
Human, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00410-5
100 µg/vial
Cat # A00410-5
100 µg/vial
TNFRSF10B Overview
Facts about Tumor necrosis factor receptor superfamily member 10B.
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor.
The consequent death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Gene Information
| Human | |
|---|---|
| Gene Name: | TNFRSF10B |
| Uniprot: | O14763 |
| Entrez: | 8795 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD262 antigen; CD262; death domain containing receptor for TRAIL/Apo-2L; Death receptor 5; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; KILLERapoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRAIL-R2apoptosis inducing receptor TRAIL-R2; TRAILR2cytotoxic TRAIL receptor-2; TRICK2; TRICK2A; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; ZTNFR9
Molecular Weight
Mass (kDA):
47.878 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (23020133..23069031, complement) |
Tissue Specificity
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Leukemia
- Colonic Neoplasms
- Lymphoma
- Prostatic Neoplasms
- Malignant Tumor Of Colon
- Adenocarcinoma
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
Interacting Proteins
- TNFSF10
- ZDHHC15
Pathways
- Cell Death
- Induction Of Apoptosis
- Sensitization
- Pathogenesis
- Cell Cycle
- Cell Killing
- Programmed Cell Death
- Localization
- Immune Response
- Cell Cycle Arrest
- Rna Interference
- Cell Proliferation
- Methylation
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Dephosphorylation
- Demethylation
Research Areas
- Apoptosis
- Cancer
- Death Receptor Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFRSF10B
bosterbio.com/bosterbio-gene-info-cards/TNFRSF10B
References
PMID: 9285725 by Screaton G.R., et al. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.
PMID: 9311998 by Walczak H., et al. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.
3 Publications of Boster TNFRSF10B Antibodies & ELISA Kits
- PubMed ID: 31901087, Yoo I,Kye YC,Han J,Kim M,Lee S,Jung W,Hong M,Park TS,Yun CH,Ka H.Uterine epithel...
- PubMed ID: 24970806, Liu N, Zuo C, Wang X, Chen T, Yang D, Wang J, Zhu H. Oncotarget. 2014 Jul 15;5(1...
- PubMed ID: 20714870, Li J, Shen Q, Peng R, Chen R, Jiang P, Li Y, Zhang L, Lu J. J Huazhong Univ Sci ...
*More publications can be found for each product on its corresponding product page